Photolytic decomposition of indapamide

  • J Pharm Sci. 1979 Aug;68(8):1063-4. doi: 10.1002/jps.2600680840.
R Davis ,  C H Wells ,  A R Taylor
PMID: 480165 DOI: 10.1002/jps.2600680840
Abstract

Photolytic decomposition of indapamide (I) in nitrogen-flushed methanol yields 3-sulfamoyl-4-chlorobenzamide (II), 2-methylindoline (III), semicarbazide (IV), and 1-(N-formamido)-2-methylindoline (V); in oxygen-flushed methanol, II--V, 1-aminocarboxymethyl-2-methylindoline (VI), 3-sulfamoyl-4-chlorobenzoic acid (VII), methyl-3-sulfamoyl-4-chlorobenzoate (VIII), and 2-(N-acetamido)-benzoic acid (IX) are formed. A comparison is made with thermal decomposition of I.

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