Plant anticancer agents XXV. Constituents of Soulamea soulameoides

  • J Nat Prod. 1983 May-Jun;46(3):359-64. doi: 10.1021/np50027a011.
S S Handa ,  A D Kinghorn ,  G A Cordell ,  N R Farnsworth
PMID: 6619884 DOI: 10.1021/np50027a011
Abstract

Three simaroubolides, glaucarubolone (1), holacanthone (2), and isobrucein A (3) were found to be responsible for the cytotoxic and antileukemic activities observed for extracts of the wood stem, stem bark, and twigs of Soulamea soulameoides. Other cytotoxic constituents isolated include a coumarinolignan cleomiscosin A (4) and the hydroxy canthin-6-one derivative 5. Picrasin B (6) was also obtained, but was not active.