Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae

  • Mutat Res. 1980 Feb;77(2):143-8. doi: 10.1016/0165-1218(80)90131-7.
F W Larimer ,  A A Hardigree ,  W Lijinsky ,  J L Epler
PMID: 6990239 DOI: 10.1016/0165-1218(80)90131-7
Abstract

The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N'-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and 2,6-dimethyldinitrosopiperazine, in the presence of rat-liver homogenate. N-nitrosopiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, and 4-benzoyl-3,5-dimethyldinitrosopiperazine were non-mutagenic.

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