Tetrodecamycin and dihydrotetrodecamycin, new antimicrobial antibiotics against Pasteurella piscicida produced by Streptomyces nashvillensis MJ885-mF8. I. Taxonomy, fermentation, isolation, characterization and biological activities

  • J Antibiot (Tokyo). 1995 Oct;48(10):1104-9. doi: 10.7164/antibiotics.48.1104.
T Tsuchida  1 ,  H Iinuma ,  C Nishida ,  N Kinoshita ,  T Sawa ,  M Hamada ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 7490215 DOI: 10.7164/antibiotics.48.1104
Abstract

The novel antimicrobial Antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25 approximately 12.5 micrograms/liter and 1.56 approximately 6.25 micrograms/ml against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and 12 strains of P. piscicida, respectively.

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