Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi

  • J Nat Prod. 1994 Oct;57(10):1430-6. doi: 10.1021/np50112a013.
L Z Lin  1 ,  S F Hu ,  K Zaw ,  C K Angerhofer ,  H Chai ,  J M Pezzuto ,  G A Cordell ,  J Lin ,  D M Zheng
Affiliations
  • 1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.
PMID: 7528786 DOI: 10.1021/np50112a013
Abstract

From Thalictrum faberi, thalifaberidine [1], a new aporphine-benzylisoquinoline alkaloid, together with four known Alkaloids, thalifaramine [2], thalifaricine [3], thalifarazine [4], and thalifaronine [5], were isolated. Thalifaberidine [1] was identified as 6',8-desmethylthalifaberine, and its 1H- and 13C-nmr data were completely assigned through the use of one- and two-dimensional nmr techniques. Thalifaberidine [1], thalifaberine [6], and thalifasine [7] showed cytotoxic activity against several human Cancer cell lines, as well as antimalarial activity.

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