Salfredins, new aldose reductase inhibitors produced by Crucibulum sp. RF-3817. I. Fermentation, isolation and structures of salfredins

  • J Antibiot (Tokyo). 1995 Jun;48(6):439-46. doi: 10.7164/antibiotics.48.439.
K Matsumoto  1 ,  K Nagashima ,  T Kamigauchi ,  Y Kawamura ,  Y Yasuda ,  K Ishii ,  N Uotani ,  T Sato ,  H Nakai ,  Y Terui
Affiliations
  • 1. Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
PMID: 7622427 DOI: 10.7164/antibiotics.48.439
Abstract

New inhibitors of Aldose Reductase, designated salfredins A3, A4, A7, C1, C2, C3 and B11, were isolated from the fermentation broth of Crucibulum sp. RF-3817 by successive purification procedures of solvent extraction, silica gel column chromatographies and reverse-phase HPLC. Their structures were established by spectroscopic methods, including UV, SI-MS and NMR. The structures of salfredins A4 and B11 were confirmed by X-ray crystallographic analysis.

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