Yunnanxane and its homologous esters from cell cultures of Taxus chinensis var. mairei

  • J Nat Prod. 1994 Sep;57(9):1320-4. doi: 10.1021/np50111a027.
W Ma  1 ,  R W Stahlhut ,  T L Adams ,  G L Park ,  W A Evans ,  S G Blumenthal ,  G A Gomez ,  M H Nieder ,  P J Hylands
Affiliations
  • 1. PHYTOpharmaceuticals, Inc., San Carlos, California 94070-3312.
PMID: 7798969 DOI: 10.1021/np50111a027
Abstract

From cell cultures of Taxus chinensis var. mairei, yunnanxane [2 alpha, 5 alpha, 10-beta triacetoxy-14 beta-(2'-methyl-3'-hydroxyl)-butyryloxy-4(20),11-taxadiene, [1], and four new homologous esters, 2 alpha, 5 alpha, 10 beta, 14 beta- tetra-acetoxy-4(20),11-taxadiene [2], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-propionyloxy-4(20),11-taxadiene [3], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-isobutyryloxy-4(20),11- taxadiene [4], and 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-(2'-methyl)-butyryloxy-4(20),11- taxadiene [5] have been isolated. Their structures were determined by spectroscopic methods.

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