Zarzissine, a new cytotoxic guanidine alkaloid from the Mediterranean sponge Anchinoe paupertas

  • J Nat Prod. 1994 Oct;57(10):1455-7. doi: 10.1021/np50112a019.
N Bouaicha  1 ,  P Amade ,  D Puel ,  C Roussakis
Affiliations
  • 1. Universitéde Nice Sophia-Antipolis, Laboratoire de Physiologie Cellulaire et Comparée, Faculté des Sciences, Nice, France.
PMID: 7807130 DOI: 10.1021/np50112a019
Abstract

From a CH2Cl2 extract of the Mediterranean Sponge Anchinoe paupertas were isolated and characterized zarzissine [2], a new 4,5-guanidino-pyridazine compound and the known p-hydroxybenzaldehyde [1]. The structure of zarzissine [2] was elucidated by spectroscopic methods, including the application of a number of 2D nmr techniques. Biological activities of compounds 1 and 2 were also determined, with zarzissine exhibiting cytotoxicity against three human and murine tumor cell lines.

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