Darlucins A and B, new isocyanide antibiotics from Sphaerellopsis filum (Darluca filum)

  • J Antibiot (Tokyo). 1995 Jan;48(1):36-41. doi: 10.7164/antibiotics.48.36.
S Zapf  1 ,  M Hossfeld ,  H Anke ,  R Velten ,  W Steglich
Affiliations
  • 1. LB Biotechnologie der Universität, Kaiserslautern, FRG.
PMID: 7868387 DOI: 10.7164/antibiotics.48.36
Abstract

Two new xanthocillin type Antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1,2-diisocyanoalkene moiety. Both compounds exhibited Antibacterial, Antifungal and weak cytotoxic activities.

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