Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination

  • J Antibiot (Tokyo). 1994 Feb;47(2):168-72. doi: 10.7164/antibiotics.47.168.
B Nuber  1 ,  F Hansske ,  C Shinohara ,  S Miura ,  K Hasumi ,  A Endo
Affiliations
  • 1. Anorganisch-chemisches Institut, Universität, Heiderberg, Germany.
PMID: 8150712 DOI: 10.7164/antibiotics.47.168
Abstract

The elucidation of the structure of gypsetin, a new inhibitor of acyl-CoA: cholesterol Acyltransferase, is described in this paper. By spectroscopic and X-ray crystallographic analyses, the structure of gypsetin has been determined to be 8a,16a-dihydroxy-5a,13a-bis[1,1-dimethylallyl]-[1]benzazolidine [3''' 2''':4'',5'']azolidino[1'',2'':4',5'][1,4]perhydrodiazin[1', 2':1, 5]azolidino[2,3-b]-[1]benzazolidine-7,15-dione.

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