Rollinecins A and B: two new bioactive annonaceous acetogenins from Rollinia mucosa

  • J Nat Prod. 1996 May;59(5):548-51. doi: 10.1021/np960128n.
G Shi  1 ,  Q Ye ,  K He ,  J L McLaughlin ,  J M MacDougal
Affiliations
  • 1. Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
PMID: 8778247 DOI: 10.1021/np960128n
Abstract

Two new mono-THF ring acetogenins, rollinecins A (1) and B (2), were isolated from the partitioned ethanolic extracts of the leaves of Rollinia mucosa (Annonaceae) by activity-directed fractionation. 1 and 2 are epimeric at the C-14 carbinol stereocenter. Their absolute stereochemical structures were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed equivalent and selective in vitro activities against several human solid tumor cell lines.