Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii

  • J Nat Prod. 1996 Sep;59(9):839-42. doi: 10.1021/np960399y.
T Pengsuparp  1 ,  M Serit ,  S H Hughes ,  D D Soejarto ,  J M Pezzuto
Affiliations
  • 1. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
PMID: 8864237 DOI: 10.1021/np960399y
Abstract

Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 Reverse Transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.

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