Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp

  • J Antibiot (Tokyo). 1996 Sep;49(9):839-45. doi: 10.7164/antibiotics.49.839.
Y Murakami  1 ,  S Kato ,  M Nakajima ,  M Matsuoka ,  H Kawai ,  K Shin-Ya ,  H Seto
Affiliations
  • 1. Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
PMID: 8931715 DOI: 10.7164/antibiotics.49.839
Abstract

Formobactin, a new free radical scavenger, was isolated from the culture of Nocardia sp. strain ND20. The structure of formobactin was determined to be a member of the nocobactin group Antibiotics. Formobactin inhibited lipid peroxidation in rat brain homogenate. Formobactin also showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.

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