A new isopatulin derivative pintulin produced by Penicillium vulpinum F-4148 taxonomy, isolation, physico-chemical properties, structure and biological properties
- J Antibiot (Tokyo). 1996 Oct;49(10):985-9. doi: 10.7164/antibiotics.49.985.
Affiliations
- 1. Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama.
PMID: 8968391
DOI: 10.7164/antibiotics.49.985
Abstract
During our screening program of natural products from Fungal metabolites for drugs effective against tumor cell lines, we discovered a new isopatulin derivative, pintulin, from the fermentation broth of Penicillium vulpinum F-4148. Pintulin shows weak activity against tumor cell lines, compared to that of adriamycin.