Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005

  • AIDS. 1997 Feb;11(2):157-62. doi: 10.1097/00002030-199702000-00004.
D Böttiger  1 ,  N G Johansson ,  B Samuelsson ,  H Zhang ,  P Putkonen ,  L Vrang ,  B Oberg
Affiliations
  • 1. Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden.
PMID: 9030361 DOI: 10.1097/00002030-199702000-00004
Abstract

Objective: To study the possibilities and limitations of postexposure treatment to prevent the establishment of Infection after accidental exposure to HIV.

Design and methods: The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments.

Results: Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented Infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment.

Conclusion: This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.

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