Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors

  • J Med Chem. 1977 Nov;20(11):1473-7. doi: 10.1021/jm00221a022.
A M Crider ,  J M Robinson ,  H G Floss ,  J M Cassady ,  J A Clemens
PMID: 915908 DOI: 10.1021/jm00221a022
Abstract

The synthesis of several N-6 derivatives of elymoclavine (3) and potential alkylating derivatives of 6-methyl-8-aminoergolines (12) is described. These compounds were screened for prolactin-inhibiting ability and 6-propyl-8-hydroxymethyl-8-ergolene (9) was found to be as active as the most potent Prolactin inhibitors reported to date. The total synthesis of racemic methyl dihydrolysergate I (23), having a trans C, D ring fusion, from the tricyclic ketone 18 is also described.

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