Tripeptide growth hormone secretagogues

  • Bioorg Med Chem Lett. 1998 Apr 7;8(7):759-64. doi: 10.1016/s0960-894x(98)00103-6.
L Yang  1 ,  G Morriello ,  Y Pan ,  R P Nargund ,  K Barakat ,  K Prendergast ,  K Cheng ,  W W Chan ,  R G Smith ,  A A Patchett
Affiliations
  • 1. Department of Medicinal Chemistry, and Biochemistry & Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA.
PMID: 9871537 DOI: 10.1016/s0960-894x(98)00103-6
Abstract

A series of C-terminus capped Dipeptides and Tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing Peptides can be mimicked at the tripeptide level.

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