Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1337-42. doi: 10.1016/s0960-894x(98)00213-3.
J P Gotteland  1 ,  C Loubat ,  B Planty ,  D Junquéro ,  A Delhon ,  S Halazy
Affiliations
  • 1. Medicinal Chemistry Division, Centre de Recherche Pierre Fabre, Castres, France. [email protected]
PMID: 9871762 DOI: 10.1016/s0960-894x(98)00213-3
Abstract

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as Cholesterol biosynthesis inhibitors.