Conodiparines A-D, new bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells

  • Bioorg Med Chem Lett. 1998 Jul 7;8(13):1693-6. doi: 10.1016/s0960-894x(98)00294-7.
T S Kam  1 ,  K M Sim ,  T Koyano ,  M Toyoshima ,  M Hayashi ,  K Komiyama
Affiliations
  • 1. Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
PMID: 9873417 DOI: 10.1016/s0960-894x(98)00294-7
Abstract

Four new bisindoles of the vobasine-iboga type, conodiparines A-D were obtained from Tabernaemontana corymbosa which showed appreciable activity in reversing resistance in vincristine-resistant KB cells.