Development of new chromanol antagonists of leukotriene D4

  • Bioorg Med Chem Lett. 1998 Jul 21;8(14):1791-6. doi: 10.1016/s0960-894x(98)00273-x.
R J Chambers  1 ,  G W Antognoli ,  J B Cheng ,  A Marfat ,  J S Pillar ,  J T Shirley ,  J W Watson
Affiliations
  • 1. Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
PMID: 9873435 DOI: 10.1016/s0960-894x(98)00273-x
Abstract

By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).