Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents

  • Bioorg Med Chem Lett. 1998 Jul 21;8(14):1845-50. doi: 10.1016/s0960-894x(98)00320-5.
J M Elliott  1 ,  M A Cascieri ,  G Chicchi ,  S Davies ,  F J Kelleher ,  M Kurtz ,  T Ladduwahetty ,  R T Lewis ,  A M MacLeod ,  K J Merchant ,  S Sadowski ,  G I Stevenson
Affiliations
  • 1. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K. [email protected]
PMID: 9873445 DOI: 10.1016/s0960-894x(98)00320-5
Abstract

A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.