Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine

  • Bioorg Med Chem Lett. 1998 Nov 3;8(21):2961-6. doi: 10.1016/S0960-894X(98)00532-0.
J Eustache  1 ,  A Grob ,  C Lam ,  O Sellier ,  G Schulz
Affiliations
  • 1. Laboratoire de Synthèse Organique et Chimie Microbienne associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, France. [email protected]
PMID: 9873655 DOI: 10.1016/S0960-894X(98)00532-0
Abstract

The synthesis of eight rigid analogs of L-N-iminoethylornithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.