Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C

  • Bioorg Med Chem Lett. 1998 Nov 17;8(22):3245-50. doi: 10.1016/s0960-894x(98)00599-x.
S H Chen  1 ,  S Lin ,  I King ,  T Spinka ,  G E Dutschman ,  E A Gullen ,  Y C Cheng ,  T W Doyle
Affiliations
  • 1. Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA.
PMID: 9873711 DOI: 10.1016/s0960-894x(98)00599-x
Abstract

The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The Antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent Antiviral agent.