(±)-Liquiritigenin
Based on 1 Customer Validation
(±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) is a dihydroflavone flavonoid. (±)-Liquiritigenin is isolated from the aerial parts of Angelica keiskei. (±)-Liquiritigenin reduces LDH release in cells. (±)-Liquiritigenin exerts a cytoprotective effect against glucose oxidase-induced cellular oxidative stress. (±)-Liquiritigenin exhibits a tumor-promoting effect in liver cancer.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 69097-97-8
- Formula: C15H12O4
- Molecular Weight:256.26
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(±)-Liquiritigenin (0.1-100 μM; 4 days) exerts a significant dose-dependent proliferative effect on human hepatocellular carcinoma Hep3B cells, and cell viability reaches 134.54% of that in the control group at a concentration of 100 μM[1].
(±)-Liquiritigenin (0.1-100 μM; 5 h) exerts a potent dose-dependent cytoprotective effect against glucose oxidase-induced oxidative stress in human hepatocellular carcinoma Hep3B cells[1].
(±)-Liquiritigenin (0.1-100 μM; 5 h) exerts a potent dose-dependent cytoprotective effect against glucose oxidase-induced oxidative stress in the mouse fibroblast cell line NIH3T3[1].
(±)-Liquiritigenin (0.1-100 μM; 5 h) reduces glucose oxidase-induced LDH release and cytotoxicity in human hepatocellular carcinoma Hep3B cells in a dose-dependent manner[1].
(±)-Liquiritigenin (0.1-100 μM; 5 h) reduces LDH release and cytotoxicity in glucose oxidase-induced mouse fibroblast NIH3T3 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatoma Hep3B cells
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Concentration:0.1, 1, 10, 100 μM
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Incubation Time:4 days
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Result:Promoted Hep3B cell growth in a dose-dependent manner.
Achieved viable cell percentages relative to untreated control of 100.18% at 0.1 μM, 103.79% at 1 μM, 111.93% at 10 μM, and 134.54% at 100 μM.
Produced a significant growth promotion effect on Hep3B cells at 100 μM.
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Cell Line:human hepatoma Hep3B cells
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Concentration:0.1, 1, 10, 100 μM (co-incubated with 15 mU/mL GOX); 100 μM (no GOX treatment)
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Incubation Time:5 hours (co-incubated with GOX)
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Result:Reduced GOX-elicited LDH cytotoxicity in a dose-dependent manner in Hep3B cells.
Recorded LDH cytotoxicity percentages of 11.57% at 0.1 μM, 6.83% at 1 μM, 4.93% at 10 μM, and 3.82% at 100 μM with GOX.
Recorded LDH cytotoxicity of 2.64% at 100 μM without GOX.
Generated all values that were significantly lower than the corresponding results for the α-Tocopherol positive control.
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Cell Line:mouse fibroblast NIH3T3 cells
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Concentration:0.1, 1, 10, 100 μM (co-incubated with 15 mU/mL GOX); 100 μM (no GOX treatment)
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Incubation Time:5 hours (co-incubated with GOX)
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Result:Mitigated GOX-triggered LDH cytotoxicity in a dose-dependent manner in NIH3T3 cells.
Recorded LDH cytotoxicity percentages of 18.42% at 0.1 μM, 7.85% at 1 μM, 5.51% at 10 μM, and 2.63% at 100 μM with GOX.
Recorded LDH cytotoxicity of 2.75% at 100 μM without GOX.
Generated all values that were significantly lower than the corresponding results for the α-Tocopherol positive control.
Chemical Information
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CAS No. 69097-97-8
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Appearance Solid
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Molecular Weight 256.26
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Formula C15H12O4
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Color Off-white to yellow
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SMILES
O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
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Synonyms
(±)-4',7-Dihydroxyflavanone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 30 mg/mL (117.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9023 mL | 19.5114 mL | 39.0229 mL | 97.5572 mL |
| 5 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | 19.5114 mL | |
| 10 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL | 9.7557 mL | |
| 15 mM | 0.2602 mL | 1.3008 mL | 2.6015 mL | 6.5038 mL | |
| 20 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8779 mL | |
| 25 mM | 0.1561 mL | 0.7805 mL | 1.5609 mL | 3.9023 mL | |
| 30 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2519 mL | |
| 40 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4389 mL | |
| 50 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9511 mL | |
| 60 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6260 mL | |
| 80 mM | 0.0488 mL | 0.2439 mL | 0.4878 mL | 1.2195 mL | |
| 100 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9756 mL |
(±)-Liquiritigenin Related Classifications
HY-N0377A Related Classifications
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Keywords
- (±)-Liquiritigenin
- 69097-97-8
- (±)-4',7-Dihydroxyflavanone
- Lactate Dehydrogenase
- cytotoxicity
- hepatoma cells
- flavanone-type flavonoid
- α-Tocopherol
- human hepatoma Hep3B cells
- Angelica keiskei
- mouse fibroblast cells
- glucose oxidase-induced oxidative stress
- mouse fibroblast NIH3T3 cells
- LDH release
- Inhibitor
- inhibitor
- inhibit