(R)-Liquiritigenin
Based on 1 Customer Validation
(R)-Liquiritigenin ((R)-4',7-Dihydroxyflavanone) is a MAO inhibitor that acts as an inhibitor of recombinant human MAO-A (IC50 9.97 μM) and recombinant human MAO-B (IC50 3.91 μM). (R)-Liquiritigenin is applicable to the research of neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 211178-39-1
- Formula: C15H12O4
- Molecular Weight:256.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hMAO-A 9.97 μM (IC50) |
hMAO-B 3.91 μM (IC50) |
In Vitro
(R)-Liquiritigenin (0.001-100 μM; 10 min pre-incubation, 20 min enzyme-substrate incubation) preferentially inhibits recombinant human MAO-B over MAO-A, with an IC50 of 3.91 μM for MAO-B and 9.97 μM for MAO-A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 211178-39-1
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Appearance Solid
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Molecular Weight 256.25
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Formula C15H12O4
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SMILES
O=C1C[C@@H](OC2=CC(O)=CC=C12)C3=CC=C(C=C3)O
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Synonyms
(R)-4',7-Dihydroxyflavanone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : ≥ 10 mg/mL (39.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.9024 mL | 19.5122 mL | 39.0244 mL | 97.5610 mL |
| 5 mM | 0.7805 mL | 3.9024 mL | 7.8049 mL | 19.5122 mL | |
| 10 mM | 0.3902 mL | 1.9512 mL | 3.9024 mL | 9.7561 mL | |
| 15 mM | 0.2602 mL | 1.3008 mL | 2.6016 mL | 6.5041 mL | |
| 20 mM | 0.1951 mL | 0.9756 mL | 1.9512 mL | 4.8780 mL | |
| 25 mM | 0.1561 mL | 0.7805 mL | 1.5610 mL | 3.9024 mL | |
| 30 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2520 mL |
(R)-Liquiritigenin Related Classifications
HY-N0377B Related Classifications
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