1. Protein Tyrosine Kinase/RTK
  2. RET
  3. RET V804M-IN-1

RET V804M-IN-1 

Cat. No.: HY-136534
Handling Instructions

RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM.

For research use only. We do not sell to patients.

RET V804M-IN-1 Chemical Structure

RET V804M-IN-1 Chemical Structure

CAS No. : 2414909-94-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
50 mg USD 580 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].

IC50 & Target

IC50: 20 nM (RETV804M)[1].

In Vitro

RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].

Molecular Weight

344.37

Formula

C₁₉H₁₆N₆O

CAS No.

2414909-94-5

SMILES

O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=CN=C4)C=CN3N=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (362.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9039 mL 14.5193 mL 29.0385 mL
5 mM 0.5808 mL 2.9039 mL 5.8077 mL
10 mM 0.2904 mL 1.4519 mL 2.9039 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

RET V804M-IN-1RETInhibitorinhibitorinhibit

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Product name:
RET V804M-IN-1
Cat. No.:
HY-136534
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