RTI-263
RTI-263 is a biased Neuropeptide S receptor agonist. RTI-263 produces anxiolytic-like effects in rodents. RTI-263 reduces cocaine-seeking behavior in both male and female rats. RTI-263 does not modulate behaviors associated with natural rewards, including palatable food intake and fasting-induced food intake in rats. RTI-263 enhances memory in rodents without inducing increased arousal. RTI-263 can be used in studies related to substance use disorders and cocaine addiction.
For research use only. We do not sell to patients.
- Formula: C22H35N7O6
- Molecular Weight:493.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RTI-263 (1 nmole) induces anxiolytic-like behavior in male Sprague-Dawley rats, as evidenced by increased time spent in the light compartment of the light-dark box[1].
RTI-263 (10 nmole) antagonizes NPS-induced hyperlocomotion in male Sprague-Dawley rats[1].
RTI-263 (intracerebroventricular injection; single administration; 1-10 nmole) significantly reduces cue-induced cocaine-seeking behavior in male Sprague-Dawley rats[1].
RTI-263 (intracerebroventricular injection; single administration; 1-10 nmole) significantly reduces cue-induced cocaine-seeking behavior in female Sprague-Dawley rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 301-325 g)[1]
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Dosage:1 nmole
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Administration:i.c.v.; single injection; 10 min before testing
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Result:Displayed no increase in locomotor activity compared to vehicle control.
Showed no significant difference in fecal boli count relative to vehicle control.
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Animal Model:Sprague-Dawley (female, 190-200 g, 8 weeks old at arrival)[1]
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Dosage:1 nmole, 10 nmole
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Administration:i.c.v.; single injection; 5 min before reinstatement testing
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Result:Significantly reduced active lever responding during cue-induced reinstatement compared to vehicle control.
Showed no significant differences in inactive lever responding relative to control.
Chemical Information
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Molecular Weight 493.56
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Formula C22H35N7O6
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SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)[C@H](CO)N
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Sequence
Ser-Phe-Lys-Asn-NH2
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Sequence Shortening
SFKN-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Huang Y, et al. RTI-263, a biased neuropeptide S receptor agonist that retains an anxiolytic effect, attenuates cocaine-seeking behavior in rats. Neuropharmacology. 2023 Dec 15;241:109743. [Content Brief]
[2]. Caragea VM, et al. Neuropeptide S modulation of learning and memory: a systematic review. Behavioral and brain functions : BBF. 2026 May 03;22(1):17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RTI-263 Related Classifications
HY-P12119 Related Classifications
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