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Cat. No.: HY-189280

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S-570

S-570 is an orally active selective STING antagonist. S-570 inhibits the secretion of the cytokines IFN-β and IL-6. S-570 can be used for research on inflammation.

For research use only. We do not sell to patients.

CAS No.: 2718206-92-7
Formula: C₁₇H₁₂ClF₃N₄
Molecular Weight:364.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-570 Chemical Structure

CAS No.: 2718206-92-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

S-570 is an orally active selective STING antagonist. S-570 inhibits the secretion of the cytokines IFN-β and IL-6. S-570 can be used for research on inflammation^[1].

IC₅₀ & Target

^[1]

IL-6

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	0.041 μM	Inhibition of human STING in human IRF-reporter HEK293 cells overexpressing human STING assessed as reduction in reporter activity by dose-response curve analysis. Inhibition of human STING in human IRF-reporter HEK293 cells overexpressing human STING assessed as reduction in reporter activity by dose-response curve analysis.	42562155
THP-1	IC50	0.018 μM	Inhibition of IFN-β secretion in 2′,3′-cGAMP-stimulated human monocyte THP-1 cells assessed by dose-response curve analysis. Inhibition of IFN-β secretion in 2′,3′-cGAMP-stimulated human monocyte THP-1 cells assessed by dose-response curve analysis.	42562155
B16	IC50	0.071 μM	Antagonist activity against mouse STING in CMA-stimulated mouse B16 cells assessed as reduction in reporter activity by dose-response curve analysis. Antagonist activity against mouse STING in CMA-stimulated mouse B16 cells assessed as reduction in reporter activity by dose-response curve analysis.	42562155

In Vitro

S-570 is a potent hSTING antagonist in HEK293 cells with an IC₅₀ of 0.041 μM^[1].
S-570 potently inhibits IFN-β secretion in 2′,3′-cGAMP (HY-100564)-stimulated THP-1 cells with an IC₅₀ of 0.018 μM^[1].
S-570 (30 min) exhibits improved stability in liver microsomes, with 44.1% remaining after 30 min^[1].
S-570 is a potent mouse STING antagonist in mouse B16 cells with an IC₅₀ of 0.071 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C₀	AUC_0-last	V_ss	CL	MRT_0-last	T_max	C_max	F
Mice^[1]	3 mg/kg	i.v.	0.616 h	8916 ng/mL	2081 ng·h/mL	0.442 L/kg	1.44 L/h/kg	0.301 h	/	/	/
Mice^[1]	30 mg/kg	p.o.	2.86 h	/	16054 ng·h/mL	/	/	1.647 h	1.00 h	7091 ng/mL	77.3 %

In Vivo

S-570 (1-30 mg/kg; p.o.) effectively attenuates systemic inflammation in a CMA-stimulated mouse model by significantly suppressing IFN-β, IL-6, and TNF-α production in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

1, 3, 10, 30 mg/kg
Administration:

p.o.
Result:

Suppressed plasma levels of IFN-β, IL-6, and TNF-α in a dose-dependent manner.

Chemical Information

CAS No. 2718206-92-7
Molecular Weight 364.75
Formula C₁₇H₁₂ClF₃N₄
SMILES

CN1C2=CC=C(C(F)(F)F)C=C2N=C1NC3=CNC4=C3C=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kiyoi T, et al. Discovery of orally available benzimidazole-based STING antagonists with in vivo activity. Bioorganic & medicinal chemistry letters. 2026 Dec;141:130757.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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S-570

All Interleukin Related Isoforms