Sabeluzole  (Synonyms: R 58735)

Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease^[1][2].

Sabeluzole (50 nM, 100 nM; 20 min before cell injury) exhibits protection in glutamate (50 μM)-mediated excitotoxicity in primary culture of cerebellar granule cell^[1].
Sabeluzole (50 nM; 7 d) inhibits tau protein level increase induced by glutamate^[1].
Sabeluzole (50 nM; 4 d) shows neuroprotective effects in human neuroblastoma cell line SH-SY5Y^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sabeluzole (5 mg/kg, 25 mg/kg; sc; twice dose with 72 h interval) shows positive and memory enhancing properties in habituation amnesia male rats induced with 20 mg/kg Chlordiazepoxide^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

415.52

C₂₂H₂₆FN₃O₂S

104383-17-7

CN(C1CCN(CC(O)COC2=CC=C(F)C=C2)CC1)C3=NC4=C(C=CC=C4)S3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103.  [Content Brief]

  [2]. Hlinák Z,et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl). 1991;104(4):505-9.  [Content Brief]