1. MAPK/ERK Pathway
    NF-κB
  2. JNK
    NF-κB
  3. Salicortin

Salicortin 

Cat. No.: HY-123503
Handling Instructions

Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity.

For research use only. We do not sell to patients.

Salicortin Chemical Structure

Salicortin Chemical Structure

CAS No. : 1887055-63-1

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Description

Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity[1].

IC50 & Target[1]

JNK

 

NF-κB

 

In Vitro

Salicortin (100 μM; 2 hours) almost completely retards the phosphorylation of IκBα[1].

Western Blot Analysis[1]

Cell Line: Mouse bone marrow macrophage (BMM)
Concentration: 100 μM
Incubation Time: 2 hours
Result: Retarded the phosphorylation of IκBα.
Molecular Weight

424.40

Formula

C₂₀H₂₄O₁₀

CAS No.

1887055-63-1

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SalicortinJNKNF-κBc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Salicortin
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