SB-334867 (Standard)
SB-334867 (Standard) is the analytical standard of SB-334867. This product is intended for research and analytical applications. SB-334867 (SB 334867A) is an excellent,selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98%
- CAS 番号: 249889-64-3
- 分子式: C17H14ClN5O2
- 分子量:355.78
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-10895
SB-334867OX1 Receptor Antagonist -
HY-70068
SB-408124OX1 Receptor Antagonist -
HY-100452
TCS-OX2-29OX2R Antagonist -
HY-10805A
Almorexant hydrochlorideOrexin Receptor Antagonist -
HY-10900
TCS 1102OX Receptor Antagonist -
HY-10805
AlmorexantOrexin Receptor Antagonist -
HY-10898
SB-674042OX1 Receptor Antagonist -
HY-10895A
SB-334867 free baseOX1 Antagonist -
HY-76612
SB-408124 HydrochlorideOX1 Receptor Antagonist -
HY-10896
JNJ-10397049OX2R Antagonist -
HY-108682
EMPAOX Receptor Antagonist -
HY-15653
FilorexantOX Receptor Antagonist
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 249889-64-3
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分子量 355.78
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分子式 C17H14ClN5O2
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SMILES
O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43.Cl
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別名
SB 334867A (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Porter RA, et al. 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10. [Content Brief]
[2]. Łupina M, et al. SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice-a View on Receptor Mechanisms. [Content Brief]
[3]. Anderson RI, et al. Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models.Front Neurosci. 2014 Feb 25;8:33. [Content Brief]
[4]. Smart D, et al. SB-334867-A: the first selective orexin-1 receptor antagonist.Br J Pharmacol. 2001 Mar;132(6):1179-82. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB-334867 (Standard) 関連分類
HY-10895R 関連分類
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