Perfluamine
Based on 1 Customer Validation
Perfluamine (Perfluorotripropylamine; FTPA; Tris (perfluoropropyl) amine) is a colorless, odorless, inert liquid with high gas-dissolving capacity. Perfluamine is non-toxic in rats, forms stable emulsions, is slowly eliminated from organs, and dissolves and transports oxygen. Perfluamine can be used to prepare oil-in-water emulsions as oxygen-carrying media. Perfluamine can be used in organic synthesis-related research, such as encapsulation in PLGA-PEG nanocarriers to obtain PLGA-PEG/FC-3283 emulsions.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 338-83-0
- Formula: C9F21N
- Molecular Weight:521.07
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Perfluamine (FTPA) was classified as forming a favorable perfluorocarbon emulsion with Pluronic F-68 and egg yolk phospholipids in a cell-free emulsion stability assay[1].
Perfluamine was encapsulated in PLGA‑PEG copolymer to prepare PLGA‑PEG/FC‑3283 emulsion; this emulsion exhibited low cytotoxicity toward HCT116 cells and significantly enhanced cell viability after hypoxic injury in a hypoxia‑reoxygenation cell model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 338-83-0
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Appearance Liquid (Density: 1.822 g/cm3)
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Molecular Weight 521.07
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Formula C9F21N
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Color Colorless to light yellow
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SMILES
FC(F)(F)C(F)(F)C(N(C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)F)(F)F
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Synonyms
Perfluorotripropylamine; FTPA; Tris(perfluoropropyl)amine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (191.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9191 mL | 9.5956 mL | 19.1913 mL | 47.9782 mL |
| 5 mM | 0.3838 mL | 1.9191 mL | 3.8383 mL | 9.5956 mL | |
| 10 mM | 0.1919 mL | 0.9596 mL | 1.9191 mL | 4.7978 mL | |
| 15 mM | 0.1279 mL | 0.6397 mL | 1.2794 mL | 3.1985 mL | |
| 20 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3989 mL | |
| 25 mM | 0.0768 mL | 0.3838 mL | 0.7677 mL | 1.9191 mL | |
| 30 mM | 0.0640 mL | 0.3199 mL | 0.6397 mL | 1.5993 mL | |
| 40 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1995 mL | |
| 50 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9596 mL | |
| 60 mM | 0.0320 mL | 0.1599 mL | 0.3199 mL | 0.7996 mL | |
| 80 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL | |
| 100 mM | 0.0192 mL | 0.0960 mL | 0.1919 mL | 0.4798 mL |
Perfluamine Related Classifications
HY-108299 Related Classifications
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Keywords
- Perfluamine
- 338-83-0
- Perfluorotripropylamine
- FTPA
- Tris(perfluoropropyl)amine
- Biochemical Assay Reagents
- Drug Intermediate
- HCT 116 cells
- cell viability
- cytotoxicity
- hypoxia
- hypoxia/reoxygenation injury
- oxygen carrier
- oxygen solubility
- perfluorochemical emulsion
- rats
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit