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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
Set7
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "Set7" in MCE Product Catalog:
4
4 Cited Publications
別名: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP
Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication . Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation .
4
4 Cited Publications
Target:
研究分野:
CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity .
4
4 Cited Publications
Target:
研究分野:
CARM1-IN-1 (compound 7g) hydrochloride is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 hydrochloride inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 hydrochloride also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity .
2
2 Cited Publications
Target:
研究分野:
UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E .
1
1 Cited Publications
製品番号: HY-P74613
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: KMT5A; Lysine N-Methyltransferase 5A; Prev. SetD8; H4-K20-HMTase KMT5A; PR-Set7; PR/Set07; Set07; [Histone H4]-Lysine(20) N-Methyltransferase; Set8; H4-K20-Specific Histone Methyltransferase; Set Domain Containing (Lysine Methyltransferase) 8; Histone-Lys
Species:
Human
Source:
E. coli
Target:
研究分野:
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity .
製品番号: HY-172614
CAS 番号: 313527-11-6
別名: RK-552
Target:
研究分野:
RK-0080552 (RK-552) is a NSD2 inhibitor with an IC50 of 0.11 μM, and it exhibits selectivity over histone methyltransferases G9a (IC50: 1.2 μM) and SET7/9 (IC50: >50 μM). RK-0080552 functionally inhibits NSD2 histone methyltransferase activity, reduces the dimethylation level of histone H3 lysine 36, suppresses IRF4 transcription, induces apoptosis and triggers cell death. RK-0080552 inhibits the growth of xenograft tumors and prolongs host survival. RK-0080552 is available for the research of multiple myeloma .
製品番号: HY-119164
CAS 番号: 832109-48-5
DC-S238 is an orally active and highly selective histone methyltransferase SET7 (SETD7) inhibitor (IC50=4.88 μM). DC-S238 is promising for research of cancer, diabetes and inflammatory diseases .
製品番号: HY-118715
CAS 番号: 1313802-67-3
Target:
研究分野:
Setin-1 is one of the most potent inhibitors of Set7, acting by inhibiting KMTase G9a .
製品番号: HY-133567
CAS 番号: 2567886-53-5
Target:
SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer .
製品番号: HY-125105
CAS 番号: 178803-91-3
Target:
研究分野:
DC-S100 is a potent SET7 inhibitor with an IC50 of 30.04 μM. DC-S100 binds to the cofactor (SAM) binding site of SET7 and forms hydrogen bonds and hydrophobic interactions with residues at this site. DC-S100 is applicable to biological studies of epigenetics and related diseases .
製品番号: HY-W013500
CAS 番号: 1215-07-2
別名: alpha-Nitrostilbene; α-Nitrostilbene; NSC 385
Target:
研究分野:
(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50=11 μM in histone H4 methylation assay). It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.
製品番号: HY-RS12747
Target:
研究分野:
SETD7 Human Pre-designed siRNA Set A contains three designed siRNAs for SETD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-P76062
純度: ≥ 95%, as determined by Bis-Tris PAGE.
別名: SetD7; KIAA1717; Set Domain Containing 7, Histone Lysine Methyltransferase; Set9; Set7/9; Set Domain Containing Lysine Methyltransferase 7; Set7; Lysine N-Methyltransferase 7; KMT7; H3-K4-HMTase SetD7; Histone-Lysine N-Methyltransferase SetD7; Set Domain
Species:
Human
Source:
E. coli
製品番号: HY-P705547
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: SetD7; KIAA1717; Set Domain Containing 7, Histone Lysine Methyltransferase; Set9; Set7/9; Set Domain Containing Lysine Methyltransferase 7; Set7; Lysine N-Methyltransferase 7; KMT7; H3-K4-HMTase SetD7; Histone-Lysine N-Methyltransferase SetD7; Set Domain
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
