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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2031 Results for "
NF-KB
" in MedChemExpress (MCE) Product Catalog:
Products (2031)
2031 Results for "NF-KB" in MCE Product Catalog:
Cat. No.: HY-P76562
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11A; Familial Expansile Osteolysis; Prev. LOH18CR1; Paget Disease Of Bone 2; Prev. PDB2; TRANCE Receptor; RANK; Tumor Necrosis Factor Receptor Superfamily, Member 11a, Activator Of NFKB; ODFR; Receptor Activator Of Nuclear Factor Kappa B; Osteoclast
Species:
Rat
Source:
HEK293
Cat. No.: HY-P76563
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11A; Familial Expansile Osteolysis; Prev. LOH18CR1; Paget Disease Of Bone 2; Prev. PDB2; TRANCE Receptor; RANK; Tumor Necrosis Factor Receptor Superfamily, Member 11a, Activator Of NFKB; ODFR; Receptor Activator Of Nuclear Factor Kappa B; Osteoclast
Species:
Rat
Source:
HEK293
Cat. No.: HY-P76986
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NFKBIB; TR-Interacting Protein 9; NFKB Inhibitor Beta; I-Kappa-B-Beta; TRIP9; NF-Kappa-BIB; IKBB; IkappaBbeta; NF-Kappa-B Inhibitor Beta; IKB-Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; TRIP-9; Thyroid Recepto
Species:
Human
Source:
E. coli
Cat. No.: HY-162946
Research Areas:
Cat. No.: HY-P71912U
Purity: ≥ 95%, as determined by reducing SDS-PAGE.; ≥ 90%, as determined by MALS.
Synonyms: TNFRSF11A; Familial Expansile Osteolysis; Prev. LOH18CR1; Paget Disease Of Bone 2; Prev. PDB2; TRANCE Receptor; RANK; Tumor Necrosis Factor Receptor Superfamily, Member 11a, Activator Of NFKB; ODFR; Receptor Activator Of Nuclear Factor Kappa B; Osteoclast
Species:
Human
Source:
HEK293
Cat. No.: HY-W097625R
CAS No.: 26964-24-9
Synonyms: PF-00932239
R-IMPP (PF-00932239) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
Cat. No.: HY-101354A
CAS No.: 2173005-10-0
Synonyms: PF-00932239 hydrochloride
Research Areas:
R-IMPP hydrochloride (PF-00932239 hydrochloride) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP hydrochloride inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP hydrochloride reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP hydrochloride increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP hydrochloride inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP hydrochloride can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
Cat. No.: HY-153858
CAS No.: 2470433-36-2
Research Areas:
PHI-501 is a dual inhibitor targeting RAF/DDR. PHI-501 exhibits significant anti-proliferative effects in melanoma cell lines and significantly inhibits the colony formation of drug-resistant cells. PHI-501 strongly inhibits ERK and AKT phosphorylation. PHI-501 downregulates the gene sets in drug-resistant cells of TNFA-NFKB, IL6-JAK-STAT3, and KRAS signaling pathways as well as the epithelial-mesenchymal transition (EMT) signaling pathways. PHI-501 demonstrates significant anti-tumor effects in the SK-MEL3DR xenograft model. PHI-501 can be used for research on the problem of drug resistance in melanoma .
Cat. No.: HY-P12219
Synonyms: OP449
Research Areas:
COG449 (OP449) is a cell-penetrating peptide that binds to SET, prevents the formation of the SET-PP2A complex, and restores PP2A phosphatase activity. COG449 decreases the phosphorylation levels of AKT 308, ERK1/2, NFkB p65, and c-MYC S62, and reduces c-MYC stability and target gene expression. COG449 induces apoptosis, autophagy, and histone H3 hyperacetylation, and decreases the levels of SET, CIP2A, SETBP1, and Mcl-1. COG449 reduces cancer cell viability and decreases tumor mass in xenograft models. COG449 can be used for research on various cancers such as oral squamous cell carcinoma, T-cell acute lymphoblastic leukemia, B-CLL, non-Hodgkin lymphoma, and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
