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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
318 Results for "
CE
" in MedChemExpress (MCE) Product Catalog:
Products (318)
318 Results for "CE" in MCE Product Catalog:
Cat. No.: HY-W791715
CAS No.: 808132-80-1
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(2r,3s,5r)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(methylamino)-6-oxo-1,6-dihydro-9h-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-W794486
CAS No.: 151132-95-5
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(2r,3r,4r,5r)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-Butyldimethylsilyl)oxy)-5-(9h-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-134833
CAS No.: 1643975-46-5
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(2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(((E)-(diisobutylamino)methylene)amino)thieno[3,4-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-154388
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5’-O-DMTr-2’-O-TBDMS-5-methoxyuridine-3’-(cyanoethyl-N,N-diisopropyl)phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-W592836
CAS No.: 2891563-60-1
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(1R,3R,4R,7S)-3-(6-Amino-2-fluoro-9H-purin-9-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-201028
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(2R,3R,4R,5R)-2-(2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-4-fluoro-5-(5-methoxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-201029
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(2R,3R,4S,5S)-2-(2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-W784563
CAS No.: 2143457-28-5
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(2R,3R,4R,5R)-5-(5-(1,3-Dioxan-2-yl)-4-(4-methoxybenzamido)-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) (R)-diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Target:
Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis
Research Areas:
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .
Cat. No.: HY-W708033
CAS No.: 1539266-39-1
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25E-NBOMe hydrochloride is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. 25E-NBOMe hydrochloride is a selective /b>5-HT2A receptor agonist.
Cat. No.: HY-W797297
CAS No.: 220382-28-5
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(2r,3r,4r,5r)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-Butyldimethylsilyl)oxy)-5-(4-(4-chlorophenoxy)-2-oxopyrimidin-1(2h)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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Dibromsalicil (Compound 31) is a carboxylesterase (CES) inhibitor with activity of 72.7 nM against hiCE (human intestinal carboxylesterase) and 53.5 nM against rCE (rabbit liver carboxylesterase). Dibromsalicil has almost no activity against hCE1 (human liver carboxylesterase) and cholinesterase .
Cat. No.: HY-W013059S1
Synonyms: DA-CE phosphoramidite-15N5
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .
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1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .
Cat. No.: HY-126182
CAS No.: 42399-40-6
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Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species .
Cat. No.: HY-N1951R
CAS No.: 27210-57-7
Synonyms: Rosmariquinone (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
