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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3408 Results for "
tight junction complex disassembly
" in MedChemExpress (MCE) Product Catalog:
Products (3408)
3408 Results for "tight junction complex disassembly" in MCE Product Catalog:
Cat. No.: HY-182959
Research Areas:
Hsp70TAC PD-1 Degrader-2 is a PD-L1 Hsp70TAC (Hsp70-targeting Chimeras) degrader with Kd values of 0.36 μM. Hsp70TAC PD-1 Degrader-2 forms a ternary complex with Hsp70 and PD-L1 to drive PD-L1 degradation. Hsp70TAC PD-1 Degrader-2 induces degradation of mature membrane-bound PD-L1 in an Hsp70-dependent manner and via caveolin-mediated endocytosis and lysosomal trafficking. Hsp70TAC PD-1 Degrader-2 accumulates preferentially in tumor cells with elevated Hsp70 expression for tumor-selective PD-L1 degradation. Hsp70TAC PD-1 Degrader-2 can be used for the research of cancer, such as breast invasive carcinoma, glioblastoma multiforme, diffuse large b-cell lymphoma . (Pink: PD-1/PD-L1 ligand (HY-19745A); Blue: Hsp70 ligand (HY-182979); Black: linker (HY-182982)).
Cat. No.: HY-187731
CAS No.: 685141-23-5
BXL0124 is an orally effective CD44 inhibitor and Notch signaling pathway inhibitor. BXL0124 has a vitamin D receptor-dependent mechanism and can downregulate the expression of CD44, Notch1/2/3, HES1, OCT4, LAMA5, JAG1, JAG2, NF-κB and DLL1. BXL0124 inhibits c-Myc expression and the levels of phosphorylated ERK, AKT, ErbB2, reduces the level of activated Notch1 receptor and its nuclear localization, decreases the mRNA and protein levels of Jagged-1 and Jagged-2, and inhibits the STAT3 signaling pathway by reducing the formation of the CD44-STAT3-JAK2 complex, while also inhibiting the transcriptional activity of the CD44 promoter in a p53-dependent manner. BXL0124 can induce myoepithelial differentiation and inhibit the self-renewal of cancer stem cell-like cells, cancer cell proliferation, invasion, and growth. BXL0124 can be used in research related to triple-negative breast cancer, basal-like breast cancer, ErbB2-overexpressing mammary tumorigenesis, and breast cancer .
Cat. No.: HY-W657887
CAS No.: 154866-92-9
Target:
Histone Methyltransferase GSK-3 Tau Protein Amyloid-β Glucocorticoid Receptor Androgen Receptor Adrenergic Receptor
Research Areas:
GSK-3β/G9a-IN-1 (Compound T2) is an orally active, selective, blood-brain-barrier permeable, competitive G9a (substrate-competitive, IC50: 1.1 μM) and GSK-3β (ATP competitive, IC50: 0.8 μM) inhibitor. GSK-3β/G9a-IN-1 is a potent H3K9me2 inhibitor that reshapes chromatin landscape. GSK-3β/G9a-IN-1 lowers tau phosphorylation, reduces Aβ aggregation. GSK-3β/G9a-IN-1 displays inhibition toward glucocorticoid receptor, androgen receptor, and alpha-2A adrenergic receptor. GSK-3β/G9a-IN-1 also upregulates SAGA complex members such as Eny2 and Sgf29. GSK-3β/G9a-IN-1 markedly improves memory, restores social behaviors, and increases synaptic complexity in late-onset Alzheimer’s disease .
Cat. No.: HY-P85527
Synonyms: BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; HRAD51; HsRad51; HsT16930; MRMV2; Rad 51; RAD51; RAD51 homolog; RecA homolog, E. coli; S. cerevisiae; RAD51 homolog A; RAD51 homolog; RAD51 recombinase; RAD51, S. cerevisiae, homolog of; RAD51_HUMAN; RAD51A; RECA; RecA like protein; RecA, E. coli, homolog of; Recombination protein A.
Cat. No.: HY-P85957
Synonyms: BAF47; BRG1-associated factor 47; hSNF5; INI1; Integrase interactor 1 protein; Malignant rhabdoid tumor suppressor; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5_HUMAN; SNF5L1; Snr1; Sucrose nonfermenting yeast homolog like 1; SWI/SNF complex component SNF5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4
Cat. No.: HY-P86959
Synonyms: Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; MED12_HUMAN antibody; Mediator complex subunit 12 antibody; Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody
Cat. No.: HY-P7S1354
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: S100A9; 60B8AG; Prev. CAGB; CGLB; Prev. CFAG; MIF; MRP-14; NIF; MRP14; Protein S100-A9; P14; Calgranulin B; Migration Inhibitory Factor-Related Protein 14; S100 Calcium-Binding Protein A9 (Calgranulin B); Leukocyte L1 complex Heavy Chain; S100 Calcium-Binding Protein A9; Calprotectin L1H Subunit; Calgranulin-B; S100-A9; L1AG; MAC387; S100 Calcium Binding Protein A9; LIAG
Species:
Rat
Source:
E. coli
Cat. No.: HY-P811903A
Synonyms: RMND5A; Required For Meiotic Nuclear Division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-P80984
Synonyms: CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; type II cytoskeletal 5 ; Type-II keratin Kb5;
Cat. No.: HY-P83701
Synonyms: HLA class I histocompatibility antigen E alpha chain antibody;
EA1.2 antibody;
EA2.1 antibody;
HLA 6.2 antibody;
HLA class I histocompatibility antigen alpha chain E antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA6.2 antibody;
HLAE antibody;
Lymphocyte antigen antibody;
Major histocompatibility complex class I E antibody;
MHC antibody;
MHC class I antigen E antibody;
MHC HLA E alpha 1 antibody;
MHC HLA E alpha 2.1 antibody;
QA1 antibody;
Cat. No.: HY-P812022
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
Cat. No.: HY-P812022A
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
Cat. No.: HY-P86889
Synonyms: Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; GPSA antibody; Gs alpha subunit antibody; GSA antibody; GSP antibody; Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms short antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas antibody; Guanine nucleotide regulatory protein antibody; MGC33735 antibody; NESP antibody; NESP55 antibody; Neuroendocrine secretory protein antibody; PHP1A antibody; PHP1B antibody; PHP1C antibody; POH antibody; Protein ALEX antibody; Protein GNAS antibody; Protein NESP55 antibody; SCG6 antibody; Secretogranin VI antibody; XLalphas antibody; XLas antibody;
Cat. No.: HY-P73138
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGFBP3; Binding Protein 53; Insulin Like Growth Factor Binding Protein 3; Binding Protein 29; IBP3; IGFBP-3; Insulin-Like Growth Factor-Binding Protein 3; IBP-3; IGF-Binding Protein 3; CDNA FLJ43234 Fis, Clone HCHON2002964, Highly Similar To Insulin-Like Growth Factor-Binding Protein 3; BP-53; Insulin-Like Growth Factor Binding Protein 3, Isoform CRA_b; Acid Stable Subunit Of The 140 K IGF complex; Insulin-Like Growth Factor Binding Protein 3; Growth Hormone-Dependent Binding Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P80243
Synonyms: cytoplasmic 1 antibody;
MGC138448 antibody;
NF ATc antibody;
NF ATc1 antibody;
NF-ATc antibody;
NF-ATc1 antibody;
NF-ATc1.2 antibody;
NFAC1_HUMAN antibody;
NFAT 2 antibody;
NFAT transcription complex cytosolic component antibody;
NFATC 1 antibody;
NFATc antibody;
NFATc1 antibody;
Nuclear factor of activated T cells cytoplasmic 1 antibody;
Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1 antibody;
Nuclear factor of activated T cells cytosolic component 1 antibody;
nuclear factor of activated T-cells 'c' antibody;
Nuclear factor of activated T-cells antibody
Cat. No.: HY-P811931
Synonyms: CHCHD6; Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6; CHCM1; PPP1R23; MICOS25; Mic25; Mitochondrial Contact Site And Cristae Organizing System Subunit 25; Coiled-Coil-Helix Cristae Morphology Protein 1; Protein Phosphatase 1, Regulatory Subunit 23; MICOS complex Subunit MIC25; MGC13016; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6; Coiled-Coil-Helix Cristae Morphology 1; Coiled Coil Helix Cristae Morphology 1; MIC25
Cat. No.: HY-P811931A
Synonyms: CHCHD6; Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6; CHCM1; PPP1R23; MICOS25; Mic25; Mitochondrial Contact Site And Cristae Organizing System Subunit 25; Coiled-Coil-Helix Cristae Morphology Protein 1; Protein Phosphatase 1, Regulatory Subunit 23; MICOS complex Subunit MIC25; MGC13016; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6; Coiled-Coil-Helix Cristae Morphology 1; Coiled Coil Helix Cristae Morphology 1; MIC25
Cat. No.: HY-P86790
Synonyms: BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; FANCD1 gene antibody; Fanconi anemia complementation group D1 antibody; Fanconi anemia group D1 protein antibody; GLM3 antibody; mutant BRCA2 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody; PNCA2 antibody; XRCC11 antibody;
Cat. No.: HY-P86957
Synonyms: CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 complex antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 complex antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; Methyl CpG binding protein splice variant 1 antibody; Methyl CpG binding protein splice variant 2 antibody; Methyl CpG binding protein splice variant 3 antibody; Methyl CpG binding protein splice variant 4 antibody; Methyl-CpG-binding domain protein 1 antibody; Methyl-CpG-binding protein MBD1 antibody; PCM 1 antibody; PCM1 antibody; Protein containing methyl-CpG-binding domain 1 antibody; Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody; RFT antibody; The regulator of fibroblast growth factor 2(FGF 2) transcription antibody;
Cat. No.: HY-P83719
Synonyms: DKFZp459C139 antibody;
EC 3.4.25.1 antibody;
LMPX antibody;
Macropain epsilon chain antibody;
MB1 antibody;
MGC104214 antibody;
MGC118075 antibody;
MGC134464 antibody;
Multicatalytic endopeptidase complex epsilon chain antibody;
Proteasome (prosome, macropain) subunit, beta type, 5 antibody;
Proteasome beta 5 subunit antibody;
Proteasome catalytic subunit 3 antibody;
Proteasome chain 6 antibody;
Proteasome epsilon chain antibody;
Proteasome subunit beta type-5 antibody;
Proteasome subunit MB1 antibody;
Proteasome subunit X antibody;
Proteasome subunit, beta type, 5 antibody;
Proteasome subunit, beta-5 antibody;
PSB5_HUMAN antibody;
PSMB5 antibody;
PSX large multifunctional protease X antibody;
X antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
