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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
387 Results for "
Chelating
" in MedChemExpress (MCE) Product Catalog:
Products (387)
387 Results for "Chelating" in MCE Product Catalog:
Cat. No.: HY-W133968
CAS No.: 9003-04-7
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Polyacrylate sodium is a sodium polyacrylate salt with extremely strong hygroscopicity. Polyacrylate sodium serves as a gel excipient and can be used as a pharmaceutical excipient. Polyacrylate sodium can reduce permeability by modifying bentonite to form a cavity-containing microstructure, while improving the chemical resistance, cation exchange capacity, and free swelling index of bentonite. Polyacrylate sodium can enhance the water retention capacity, available water content, and top-layer water content of sandy soil, while reducing the saturated hydraulic conductivity, wetting front advance rate, and infiltration rate. Polyacrylate sodium can chelate Cu 2+ ions in aqueous solutions and has renewable adsorption capacity. Polyacrylate sodium is widely used in researches related to various fields such as consumer products, agriculture, and industry .
Cat. No.: HY-W587784
CAS No.: 542-40-5
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DP-b99 is a blood-brain barrier-permeable inhibitor of CYP2C9 and MMP-9, with a Ki value of 4.655 μM against CYP2C9. DP-b99 inhibits CYP2C9 via apparent non-competitive inhibition, mainly chelates pathological Zn 2+ in the membrane environment, attenuates the elevation of intracellular Zn 2+ and Ca 2+ levels, delays seizure onset and reduces seizure severity, and also prevents MMP-9-dependent dendritic spine remodeling, β-dystroglycan cleavage and gelatinase activity. DP-b99 can be used in the research of acute ischemic stroke, epileptogenesis and stroke .
Cat. No.: HY-183760
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AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC50 of 73.65 μM against electric eel-derived AChE and an IC50 of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu 2+, Ca 2+, Mg 2+, Fe 2+ and Zn 2+. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases .
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Magnesium malate is an orally active organic acid-chelated magnesium complex. Magnesium malate promotes the release of prostaglandin E2 (PGE2) from macrophages, synergistically stimulates the synthesis/release of calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and upregulates the osteogenic transcription factor RUNX2 in osteoblasts via the Mg 2+-PGE2-CGRP axis, thereby promoting osteoblast proliferation. Magnesium malate can be incorporated into calcium phosphate bone cement as a modifying component to improve compressive strength, shorten setting time and enhance disintegration resistance. Magnesium malate increases serum magnesium levels. Magnesium malate can be used in studies related to bone defects and magnesium deficiency .
Cat. No.: HY-187430
CAS No.: 2977213-17-3
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Dopamine D2 receptor agonist-4 is a blood-brain barrier permeable Dopamine D2 receptor agonist with an EC50 value of 0.03 nM. Dopamine D2 receptor agonist-4 reduces intracellular cAMP levels. Dopamine D2 receptor agonist-4 acts as a Ferroptosis inhibitor and iron chelator, selectively chelating iron ions, reducing intracellular ferrous ion levels, and exerting cytoprotective effects against iron-dependent ferroptosis in vitro. Dopamine D2 receptor agonist-4 improves motor dysfunction and exerts neuroprotective effects in mouse models of Parkinson's disease. Dopamine D2 receptor agonist-4 can be used in studies related to Parkinson's disease .
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Cat. No.: HY-N0373R
CAS No.: 58749-23-8
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Clove oil (Clove leaf oil,rectified) is a volatile aromatic essential oil with antibacterial, anti-inflammatory and antioxidant activities. Clove oil disrupts the integrity of bacterial cell membranes, releases intracellular nucleic acids and proteins, and inhibits bacterial growth and reproduction. Clove oil scavenges DPPH, ABTS, superoxide anions, hydrogen peroxide and hydroxyl radicals. Clove oil reduces Fe 3+ to Fe 2+, chelates Fe 2+ and iron ions, and inhibits lipid peroxidation in linoleic acid emulsions. Clove oil acts as a natural preservative to reduce the loss of oxidation products. Clove oil can be isolated from the flowers, stems and leaves of Eugenia aromatica and Eugenia caryophyllus, which belong to the Myrtaceae family. Clove oil can be used in studies related to bacterial infection, antioxidation and preservation .
Cat. No.: HY-P10792
CAS No.: 1644155-35-0
Cat. No.: HY-P11853
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cRY9M is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
Cat. No.: HY-P11853A
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cRY9M acetate is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M acetate binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M acetate displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M acetate can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
Cat. No.: HY-W047709
CAS No.: 140-07-8
Synonyms: THEED; THEEN
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections .
Cat. No.: HY-W800693
CAS No.: 2841143-99-3
Cat. No.: HY-W800697
CAS No.: 2644752-87-2
Cat. No.: HY-W717743
CAS No.: 913528-04-8
Synonyms: Reutericycline
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
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Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a Kd value of 5.13e-08 M) and competitive PGP-1 inhibitor (Ki = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones .
Cat. No.: HY-121858
CAS No.: 34441-14-0
Cat. No.: HY-170779
CAS No.: 3078291-78-5
DOTA-NI-FAPI-04 is a FAP inhibitor (IC50 = 7.44 nM). By integrating FAP targeting with hypoxia-sensitive groups (nitroimidazole), DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes (such as 68Ga and 177Lu) through DOTA to produce radioactive probes ([68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
