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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
66 Results for "
AUTOTAXIN
" in MedChemExpress (MCE) Product Catalog:
Products (66)
66 Results for "AUTOTAXIN" in MCE Product Catalog:
Cat. No.: HY-135088
CAS No.: 2156655-86-4
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Autotaxin-IN-4 (compound 51), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-4 has the potential to treat idiopathic pulmonary fibrosis .
Cat. No.: HY-123522
CAS No.: 1359983-15-5
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PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo .
Cat. No.: HY-142644
CAS No.: 1646784-47-5
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ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
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BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1 .
Cat. No.: HY-135089
CAS No.: 2156655-99-9
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Autotaxin-IN-5 (compound 63), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-5 has the potential to treat idiopathic pulmonary fibrosis .
Cat. No.: HY-123637
CAS No.: 1619971-30-0
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Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain .
Cat. No.: HY-170227
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Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .
Cat. No.: HY-103267A
CAS No.: 1096770-84-1
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S32826 is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes .
Cat. No.: HY-157997
CAS No.: 460999-85-3
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MHC02181 is a potent inhibitor of Autotaxin (ATX), with IC50 of 9.41 μM .
Cat. No.: HY-158001
CAS No.: 1380881-85-5
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MHC00188 is an allosteric inhibitor for Autotaxin (ATX) with an IC50 of 2.53 μM .
Cat. No.: HY-146122
CAS No.: 2691937-01-4
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ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC50 of 156 nM .
Cat. No.: HY-146124
CAS No.: 2691936-89-5
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ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC50 of 3490 nM .
Cat. No.: HY-RS04388
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ENPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for ENPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-139096
CAS No.: 1306684-90-1
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4-Pentadecylbenzylphosphonic acid is an Autotaxin (ATX) inhibitor. 4-Pentadecylbenzylphosphonic acid has antitumor activity .
Cat. No.: HY-146123
CAS No.: 2691937-03-6
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ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM .
Cat. No.: HY-103267R
CAS No.: 1103672-43-0
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S32826 (disodium) (Standard) is the analytical standard of S32826 (disodium). This product is intended for research and analytical applications. S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 disodium inhibits LPA release from adipocytes .
Cat. No.: HY-143581
CAS No.: 2156656-37-8
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ATX inhibitor 8 is a Autotaxin (ATX) inhibitor extracted from patent WO2018212534A1 compound 96 .
Cat. No.: HY-149018
CAS No.: 2969213-59-8
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ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) with IC50 of 218 nM but lost its inhibitory activity of LPAR1 .
Cat. No.: HY-169300
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KR-40795 is a potent inhibitor of ATX (autotaxin), with the IC50 of 0.13 μM. KR-40795 plays an important role for liver diseases .
Cat. No.: HY-101772R
CAS No.: 1628260-79-6
Synonyms: GLPG1690 (Standard)
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Ziritaxestat (Standard) is the analytical standard of Ziritaxestat. This product is intended for research and analytical applications. Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
