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United States

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Cat. No.: HY-169300

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KR-40795

KR-40795 is a potent inhibitor of ATX (autotaxin), with the IC₅₀ of 0.13 μM. KR-40795 plays an important role for liver diseases.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₀ClNO₅
Molecular Weight:461.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KR-40795 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

KR-40795 is a potent inhibitor of ATX (autotaxin), with the IC₅₀ of 0.13 μM. KR-40795 plays an important role for liver diseases^[1].

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

Molecular Weight 461.89
Formula C₂₆H₂₀ClNO₅
SMILES

O=C1C/C(C(N1C2=CC(Cl)=CC=C2)=O)=C/C3=CC=CC=C3OCC4=CC=C(C=C4)C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Seung Hyeong Lee, et al. Design, synthesis and evaluation of 3-(2-(substituted benzyloxy)benzylidene) pyrrolidine-2,5-dione derivatives for novel ATX inhibitor. Bioorg Med Chem Lett. 2024 Oct 28:114:130006. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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