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Cat. No.: HY-157997

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MHC02181

MHC02181 is a potent inhibitor of Autotaxin (ATX), with IC₅₀ of 9.41 μM.

For research use only. We do not sell to patients.

CAS No.: 460999-85-3
Formula: C₂₀H₁₂ClN₃O₃S₂
Molecular Weight:441.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MHC02181 Chemical Structure

CAS No.: 460999-85-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MHC02181 is a potent inhibitor of Autotaxin (ATX), with IC₅₀ of 9.41 μM^[1].

All Phosphodiesterase (PDE) Isoforms :

In Vitro

MHC02181 (100 μM) inhibits ATX by 87 %^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 460999-85-3
Molecular Weight 441.91
Formula C₂₀H₁₂ClN₃O₃S₂
SMILES

O=C(N1C2=C(SC3=C1C=C(C=C3)Cl)C=CC=C2)CSC4=NN=C(O4)C5=CC=CO5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elli-Anna Stylianaki, et al. Identification of two novel chemical classes of Autotaxin (ATX) inhibitors using Enalos Asclepios KNIME nodes. Bioorg Med Chem Lett. 2024 Mar 5:103:129690. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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MHC02181

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MHC02181 Related Classifications

HY-157997 Related Classifications