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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
CEM C7
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "CEM C7" in MCE Product Catalog:
Cat. No.: HY-147514
CAS No.: 2387902-92-1
Target:
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Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization .
Cat. No.: HY-106872
CAS No.: 126347-69-1
Synonyms: 9-Cl-TIBO
Research Areas:
R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM .
Cat. No.: HY-146316
CAS No.: 2987586-62-7
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Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .
Cat. No.: HY-163435
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Research Areas:
Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research .
Cat. No.: HY-P10596
CAS No.: 1242413-05-3
Cat. No.: HY-151190
CAS No.: 2821068-03-3
Synonyms: S1024
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Research Areas:
cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells .
Cat. No.: HY-147901
CAS No.: 2938990-92-0
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KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively .
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DNA, 5'-TGACGAGCCCAAGTTACCTTGGTGATGGTTTTTGGTGGTAACGGGGGCGGGTGAGTAGAATCTCCGCTGCCTACA-3', sodium salt
Cat. No.: HY-160055
Cat. No.: HY-N16507
CAS No.: 167782-22-1
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Cat. No.: HY-165513
CAS No.: 173268-90-1
Niruriside is a HIV REV/RRE complex inhibitor. Niruriside specifically inhibits the binding interaction between HIV REV protein and RRE RNA, with an IC50 of 3.3 μM, and shows no significant activity against the unrelated R17 capsid protein/operator RNA binding system. At the tested concentrations, Niruriside fails to protect CEM-SS cells from acute HIV-1 infection. Niruriside can be used in the research of human immunodeficiency virus (HIV) infection .
Cat. No.: HY-180566
CAS No.: 3049284-11-6
HIV-IN-13 (compound 7) is a potent HIV inhibitor with low cellular toxicity. HIV-IN-13 inhibits HIV in CEM-SS cells with an EC50 of 1.38 μM. HIV-IN-13 displays antiviral activity in hPBMCs infected with different HIV strains (EC50 = 2.01-10.7 μM), while showing low cellular toxicity (TC50 >100 μM). HIV-IN-13 can be used for HIV-infection research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
