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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
MC1
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "MC1" in MCE Product Catalog:
Cat. No.: HY-P1215
CAS No.: 212370-59-7
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Cat. No.: HY-P3605
CAS No.: 106061-19-2
Synonyms: GAP (25-53), human
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Cat. No.: HY-P5247A
Synonyms: PTP20 TFA
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Cat. No.: HY-P4764
CAS No.: 819048-44-7
Synonyms: Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
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LY2112688 (Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2) is a synthetic peptide selective melanocortin 4 receptor (MC4R) agonist with a Ki of 0.13 nM for human MC4R and Ki values of 165, 74, and 1713 nM for human MC1R, MC3R, and MC5R, respectively. LY2112688 activates MC4R-mediated cAMP signaling and promotes PYY and GLP-1 release by activating peripheral MC4R in enteroendocrine L cells; Kir7.1 signaling in MC4R neurons is involved in its sustained suppression of food intake. LY2112688 inhibits food intake in vivo and can elevate heart rate and blood pressure. LY2112688 is useful for research on obesity, energy homeostasis, and MC4R signaling [1] .
Cat. No.: HY-P4779
CAS No.: 1815617-98-1
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Cat. No.: HY-P1216
CAS No.: 207678-81-7
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Cat. No.: HY-178293
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N-Succinimidyl 3-maleimidopropionate (Compound MC1) is a Glucuronide-Gemcitabine conjugate. N-Succinimidyl 3-maleimidopropionate can be used to synthesize ADCs (such as cAc10ec-MC1). N-Succinimidyl 3-maleimidopropionate can be used in Hodgkin's lymphoma research [1].
Cat. No.: HY-P2336
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Cat. No.: HY-P2242
CAS No.: 274682-89-2
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Cat. No.: HY-P4782
CAS No.: 1815617-99-2
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Cat. No.: HY-P4784
CAS No.: 1815618-00-8
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Cat. No.: HY-15616
CAS No.: 457893-92-4
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BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation [1].
Cat. No.: HY-P11293
CAS No.: 1309855-53-5
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Cat. No.: HY-109114A
CAS No.: 2490660-87-0
Synonyms: MT-7117 phosphate
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Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation [1] .
Cat. No.: HY-P1726A
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cat. No.: HY-N16371
CAS No.: 39051-96-2
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Cat. No.: HY-RS08200
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MC1R Human Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08201
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Mc1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08202
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MC1R Rat Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
