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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
cIAP-2
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "cIAP-2" in MCE Product Catalog:
Cat. No.: HY-RS01510
Target:
Research Areas:
BIRC3 Human Pre-designed siRNA Set A contains three designed siRNAs for BIRC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P80618A
Synonyms: cIAP2; AIP1; API2; BIRC3; cIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2
Cat. No.: HY-RS01508
Target:
Research Areas:
Birc2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-110346R
CAS No.: 1883545-51-4
Target:
Research Areas:
AZD5582 dihydrochloride (Standard) is the analytical standard of AZD5582 (dihydrochloride) (HY-110346). This product is intended for research and analytical applications. AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .
Cat. No.: HY-12440
CAS No.: 1363145-46-3
HM90822 is an orally active IAP antagonist. HM90822 induces ubiquitination and proteasome-dependent degradation of XIAP, cIAP1 and cIAP2 in sensitive pancreatic cancer cells. HM90822 induces Apoptotic cell death. HM90822 inhibits tumor growth in Panc-1 pancreatic cancer xenograft and orthotopic mouse models. HM90822 can be used for the research of pancreatic cancer .
Cat. No.: HY-N20712
CAS No.: 59632-76-7
Cat. No.: HY-111875R
CAS No.: 2095244-54-3
Research Areas:
SNIPER(BRD)-1 (Standard) is the analytical standard of SNIPER(BRD)-1 (HY-111875). This product is intended for research and analytical applications. SNIPER(BRD)-1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER(BRD)-1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research . (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))
Cat. No.: HY-P87673
Synonyms: API2, MIHC, RNF49, BIRC3, Baculoviral IAP repeat-containing protein 3, Apoptosis inhibitor 2, Cellular inhibitor of apoptosis 2, IAP homolog C, Inhibitor of apoptosis protein 1, RING finger protein 49, RING-type E3 ubiquitin transferase BIRC3, TNFR2-TRAF-signaling complex protein 1, C-IAP2, hIAP-1, hIAP1
Cat. No.: HY-16591R
CAS No.: 1260251-31-7
Synonyms: TL32711 (Standard)
Birinapant (Standard) is the analytical standard of Birinapant (HY-16591). This product is intended for research and analytical applications. Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
