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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
CBL-b
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "CBL-b" in MCE Product Catalog:
Cat. No.: HY-156762
CAS No.: 2815221-33-9
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Cbl-b-IN-6 (Compound 246) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.7 nM and 5.2 nM, respectively .
Cat. No.: HY-169005
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Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation .
Cat. No.: HY-173311
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Cbl-b-IN-28 (Compound B2) is an orally active Cbl-b inhibitor. Cbl-b-IN-28 promotes the secretion of cytokines such as IL-2 and enhances the function of immune cells by regulating the phosphorylation levels of key proteins in the T-cell receptor signaling pathway. Cbl-b-IN-28 can be used in research in the field of cancer immunology .
Cat. No.: HY-RS17948
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Cblb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cblb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01997
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CBLB Human Pre-designed siRNA Set A contains three designed siRNAs for CBLB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P78728
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CBLB; Signal Transduction Protein CBL-B; CBL Proto-Oncogene B; SH3-Binding Protein CBL-B; RNF56; RING Finger Protein 56; CBL-B; Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B;
Species:
Human
Source:
HEK293
Cat. No.: HY-158172
CAS No.: 3033320-00-9
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Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ligase Casitas B-lineage lymphoma proto-oncogene B (CPL-B). Cbl-b-IN-18 inhibits the phosphorylation of CPL-B (IC50< 100 nM) .
Cat. No.: HY-P5208
CAS No.: 1039381-80-0
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Cat. No.: HY-158174
CAS No.: 3033319-99-9
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Cbl-b-IN-20 (Example 50) is a casitas proto-oncogene-B ( CPL-B ) inhibitor with IC50 <100 nM .
Cat. No.: HY-183293
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Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263 .
Cat. No.: HY-179575
CAS No.: 3070411-10-5
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Cbl-b-IN-29 is an orally active CBL-B inhibitor. Cbl-b-IN-29 binds to the CBL-B active pocket. Cbl-b-IN-29 induces Jurkat cell release IL-2 with an EC50 of 159 nM, effectively inhibiting the function of immune E3 ubiquitin ligase. Cbl-b-IN-29 demonstrates robust anti-tumor efficacy in vivo with good tolerability and no observed adverse reactions. Cbl-b-IN-29 can be used for cancer immunotherapy, colorectal cancer and immune-oncology combination research .
Cat. No.: HY-184236
CAS No.: 2925237-58-5
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Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human Kd of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer .
Cat. No.: HY-P11479
CAS No.: 3029912-63-5
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Cat. No.: HY-183997
CAS No.: 2815221-18-0
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Cbl-b-IN-33 is an orally active, selective inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) with an IC50 of 7 nM and a Kd of 1.2 nM. Cbl-b-IN-33 inhibits non-phosphorylated E3 ubiquitin ligase Cbl-b, induces IL-2 activation in peripheral blood mononuclear cells, and exerts tumor growth inhibitory effects in a mouse colon cancer model. Cbl-b-IN-33 can be used for the research of colon cancer .
Cat. No.: HY-179617
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Cbl-b-IN-30 is an orally active Casitas B-lineage lymphoma-b (CBLB) inhibitor. Cbl-b-IN-30 specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity with an IC50 of 9.1 nM. Cbl-b-IN-30 can promote IL-2 secretion (EC50 = 187.5 nM) and enhance T cell activation. Cbl-b-IN-30 exerts antitumor activity and can induce immune memory. Cbl-b-IN-30 can be used for the research of colon cancer .
Cat. No.: HY-P811562
Synonyms: RNF56, Nbla00127, CBLB, E3 ubiquitin-protein ligase CBL-B, Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, RING-type E3 ubiquitin transferase CBL-B, SH3-binding protein CBL-B, Signal transduction protein CBL-B
Cat. No.: HY-RS08508
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MMAB Human Pre-designed siRNA Set A contains three designed siRNAs for MMAB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W797329
CAS No.: 2829898-76-0
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(3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinase. (3S)Lenalidomide-5-Br can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608) .
Cat. No.: HY-159617
CAS No.: 3035215-25-6
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Cbz-Pip-2C-Pip-C-Pip is a PROTAC linker. Cbz-Pip-2C-Pip-C-Pip can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .
Cat. No.: HY-RS24419
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Cblb Rat Pre-designed siRNA Set A contains three designed siRNAs for Cblb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
