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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
DMD
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "DMD" in MCE Product Catalog:
Cat. No.: HY-14842R
CAS No.: 497833-27-9
Synonyms: ITF-2357 (Standard)
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Givinostat (Standard) is the analytical standard of Givinostat. This product is intended for research and analytical applications. Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research .
Cat. No.: HY-132584A
Purity: 99.07%
Synonyms: SRP-4045 sodium
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Casimersen (SRP-4045) sodium is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen sodium binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen sodium can be used for the research of Duchenne muscular dystrophy (DMD) .
Cat. No.: HY-132585A
Synonyms: SRP-5051 sodium
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Vesleteplirsen sodium (SRP-5051 sodium) is a peptide-conjugated morpholino oligonucleotide (PPMO) that mediates exon jumping molecular effects. Vesleteplirsen sodium targets exon 51 of the DMD gene pre-mRNA, remodeling the transcript splicing process, restoring the protein translation read frame, and generating internally truncated pseudodystrophy proteins. Vesleteplirsen sodium can be used for research related to Duchenne muscular dystrophy .
Cat. No.: HY-153369
CAS No.: 1609342-18-8
Synonyms: BAY 1165747
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BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .
Cat. No.: HY-122588A
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Negamycin (hydrochloride) is a dipeptide antibiotic. Negamycin (hydrochloride) can restore dystrophin expression in skeletal and cardiac muscles in mdx Duchenne muscular dystrophy (DMD) murine model. Negamycin (hydrochloride) can bind to a partial sequence of the eukaryotic rRNA-decoding A-site. Negamycin (hydrochloride) can be studied in DMD research .
Cat. No.: HY-177659
CAS No.: 1196915-71-5
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Rimigorsen is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
Cat. No.: HY-150077
CAS No.: 3068935-32-7
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Utrophin modulator 1 is a potent utrophin modulator (upregulates utrophin protein levels), with an EC50 of 0.11 μM. Utrophin modulator 1 can be used in study of duchenne muscular dystrophy (DMD) .
Cat. No.: HY-RS18019
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Dmd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dmd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24492
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Dmd Rat Pre-designed siRNA Set A contains three designed siRNAs for Dmd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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RNA, ((2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)G-[P(S)]-sp-(2'-deoxy-2'-fluoro)G-[P(S)]-sp-Am-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-Gm-Am-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-Gm-Gm-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)U), sodium salt
Cat. No.: HY-132592A
CAS No.: 2142024-01-7
Synonyms: WVE-210201 sodium
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RNA, ((2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)G-[P(S)]-sp-(2'-deoxy-2'-fluoro)G-[P(S)]-sp-Am-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-Gm-Am-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-Gm-Gm-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)A-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)U-[P(S)]-sp-(2'-deoxy-2'-fluoro)C-[P(S)]-sp-(2'-deoxy-2'-fluoro)U)
Cat. No.: HY-132592
CAS No.: 2095270-67-8
Synonyms: WVE-210201
Cat. No.: HY-177659A
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Rimigorsen sodium is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
Cat. No.: HY-150078
CAS No.: 49676-35-9
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OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD) .
Cat. No.: HY-150237
Purity: 92.99%
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FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
Cat. No.: HY-17614R
CAS No.: 945531-77-1
Synonyms: SMT C1100 (Standard); BMN 195 (Standard); VOX-C1100 (Standard)
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Ezutromid (Standard) is the analytical standard of Ezutromid. This product is intended for research and analytical applications. Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM .
Cat. No.: HY-185921
CAS No.: 2379448-61-8
Synonyms: WVE-N531
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Bampidirsen (WVE-N531) is an antisense oligonucleotide (ASO) with a phosphorodiamidate backbone. Bampidirsen specifically induces DMD exon 53 skipping, and it can be used for the research of Duchenne muscular dystrophy .
Cat. No.: HY-101459R
CAS No.: 1359825-94-7
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RTC13 (Standard) is the analytical standard of RTC13 (HY-101459). This product is intended for research and analytical applications. RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
