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OX01914 

Cat. No.: HY-150078
Handling Instructions

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).

For research use only. We do not sell to patients.

OX01914 Chemical Structure

OX01914 Chemical Structure

CAS No. : 49676-35-9

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Description

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD)[1].

In Vitro

OX01914 (0.1, 10, 40, 50 µM; 24 h) upregulates utrophin mRNA in LUmdx and (30 µM; 24 h) H2K mdx myoblasts[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: LUmdx and H2K mdx myoblasts
Concentration: 0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
Incubation Time: 24 h
Result: Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.

Western Blot Analysis[1]

Cell Line: Human DMD cells
Concentration: 1, 3, 30 µM
Incubation Time: 24 h
Result: Increased utrophin protein levels by approximately 3-fold.
Molecular Weight

290.32

Formula

C17H14N4O

CAS No.
SMILES

O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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OX01914
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