OX01914
OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).
For research use only. We do not sell to patients.
- CAS No.: 49676-35-9
- Formula: C17H14N4O
- Molecular Weight:290.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
OX01914 (0.1, 10, 40, 50 μM; 24 h) upregulates utrophin mRNA in LUmdx and (30 μM; 24 h) H2K mdx myoblasts[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LUmdx and H2K mdx myoblasts
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Concentration:0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
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Incubation Time:24 h
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Result:Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.
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Cell Line:Human DMD cells
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Concentration:1, 3, 30 µM
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Incubation Time:24 h
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Result:Increased utrophin protein levels by approximately 3-fold.
Chemical Information
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CAS No. 49676-35-9
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Molecular Weight 290.32
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Formula C17H14N4O
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SMILES
O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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