OX01914

Cat. No.: HY-150078: FAQs
Data Sheet Handling Instructions

Molarity Calculator

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC₅₀ of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).

For research use only. We do not sell to patients.

OX01914 Chemical Structure

CAS No. : 49676-35-9

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

OX01914 (0.1, 10, 40, 50 µM; 24 h) upregulates utrophin mRNA in LUmdx and (30 µM; 24 h) H2K mdx myoblasts^[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	LUmdx and H2K mdx myoblasts
Concentration:	0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
Incubation Time:	24 h
Result:	Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.

Western Blot Analysis^[1]

Cell Line:	Human DMD cells
Concentration:	1, 3, 30 µM
Incubation Time:	24 h
Result:	Increased utrophin protein levels by approximately 3-fold.

Molecular Weight

290.32

Formula

C₁₇H₁₄N₄O

CAS No.

49676-35-9

SMILES

O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vuorinen A, et al. Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy. Eur J Med Chem. 2021 Aug 5;220:113431. [Content Brief]

OX01914 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX0191449676-35-9OX 01914OX-01914Othersduchenne muscular dystrophyDMDutrophin proteinLUmdx myoblastsH2K mdx myoblastsDMD cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks