313 Results for "

mAbs

" in MedChemExpress (MCE) Product Catalog:
Products (313)

313 Results for "mAbs" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P990110
Synonyms: Mab158

Target:  

Amyloid-β

Domaines de recherche:  

Neurological Disease

Lecanemab (Mouse IgG2a) (Mab158) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IgG2a sequence. Lecanemab (Mouse IgG2a) almost abolishes accumulation in astrocytes and rescues neurons from Aβ-induced cell death. Lecanemab (Mouse IgG2a) holds promise for research in the field of Alzheimer's disease .
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1
1 Cited Publications
Cat. No.: HY-P99025
CAS No.: 953400-68-5
Synonyms: TNX-650; MILR1444A; RG3637

Target:  

Interleukin Related

Domaines de recherche:  

Inflammation/Immunology

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .
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1
1 Cited Publications
Cat. No.: HY-P990121

Target:  

Interleukin Related

Domaines de recherche:  

Inflammation/Immunology Cancer

Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combined with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for researches on cancer and inflammation conditions such as colorectal cancer and prostatitis .
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1
1 Cited Publications
Cat. No.: HY-P99291
CAS No.: 892553-42-3
Synonyms: LM609; MEDI-522

Target:  

Integrin Apoptosis Akt

Domaines de recherche:  

Cancer

Etaracizumab (LM 609) is an αvβ3 integrin IgG mAb. Etaracizumab is developed to target αvβ3+ cancer cells via NK cell-mediated cytotoxicity. Etaracizumab sterically hinders access of large ligands to the RGD-binding pocket, without obstructing it. Etaracizumab decreases p-Akt in vitro. Etaracizumab can decrease cancer proliferation and invasion. Etaracizumab induces tumor cell apoptosis, and inhibition ofαvβ3-mediated cell adhesion, endothelial cell migration and osteoclast-mediated bone resorption. Etaracizumab can be studied in anti-tumor research against cancers such as ovarian cancer, metastatic melanoma as well as advanced solid tumors. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P99297
CAS No.: 2171034-69-6
Synonyms: ZTS-00508841

Target:  

Trk Receptor

Domaines de recherche:  

Inflammation/Immunology

Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .
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Cat. No.: HY-P99351
CAS No.: 1518996-49-0
Synonyms: Anti-MMP9 Reference Antibody (andecaliximab)

Target:  

MMP

Domaines de recherche:  

Cancer

Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) .
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Cat. No.: HY-P99480
CAS No.: 1918149-01-5
Synonyms: M7824; MSB0011359C

Target:  

TGF-β Receptor

Domaines de recherche:  

Cancer

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .
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Cat. No.: HY-132158
CAS No.: 2414594-29-7
Pureté:  96.00%
Domaines de recherche:  

Cancer

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC) .
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Cat. No.: HY-P99401
CAS No.: 1684393-04-1
Synonyms: OMP-131R10

Target:  

Wnt

Domaines de recherche:  

Cancer

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors .
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Cat. No.: HY-P990865

Target:  

CD28

Domaines de recherche:  

Inflammation/Immunology

Anti-CD28 Antibody (9.3) is an anti-human CD28 IgG2a monoclonal antibody. Anti-CD28 Antibody (9.3) can activate T cells. Anti-CD28 Antibody (9.3) can be used for research on immunology. The recommend isotype control of Anti-CD28 Antibody (9.3): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
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Cat. No.: HY-P99383
CAS No.: 1233956-13-2
Synonyms: REMD-477; AMG-477

Target:  

GCGR

Domaines de recherche:  

Metabolic Disease

Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D) .
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Cat. No.: HY-P99941
CAS No.: 2079108-44-2
Synonyms: INCMGA-00012; MGA-012

Target:  

PD-1/PD-L1

Domaines de recherche:  

Cancer

Retifanlimab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb). Retifanlimab can be used for the research of gastroesophageal adenocarcinoma (GEA) .
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Cat. No.: HY-P990302

Target:  

nAChR

Domaines de recherche:  

Inflammation/Immunology

Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models .
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Cat. No.: HY-P99611
CAS No.: 167816-91-3
Synonyms: 64G12

Target:  

IFNAR

Domaines de recherche:  

Inflammation/Immunology

Faralimomab (64G12) is an immunomodulator, and a murine anti-IFNA1 IgG1 mAb .
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Cat. No.: HY-P991312

Target:  

Ser/Thr Protease

Domaines de recherche:  

Metabolic Disease

CM-338 is a human monoclonal antibody (mAb) targeting MASP2. CM-338 can be used in IgA nephropathy research.
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Cat. No.: HY-132260
CAS No.: 1607824-64-5
Synonyms: IMGN529; Debio 1562

Domaines de recherche:  

Cancer

Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis .
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Cat. No.: HY-P99506
CAS No.: 2148325-59-9
Synonyms: SC-003 mAb; SC-Mab003; SC34.28ss1

Target:  

ADC Antibodies

Domaines de recherche:  

Cancer

Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research .
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Cat. No.: HY-P99633
CAS No.: 2342597-81-1
Synonyms: BGB-A333

Target:  

PD-1/PD-L1 Apoptosis

Domaines de recherche:  

Cancer

Garivulimab (BGB-A333) is a humanized IgG1-variant monoclonal antibody that specifically targets and binds to PD-L1. Garivulimab selectively blocks the interaction of PD-L1 and PD-1. Garivulimab has antitumor activity .
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Cat. No.: HY-150637
CAS No.: 2755712-12-8
Pureté:  99.50%
Target:  

Bacterial

Domaines de recherche:  

Infection

Mab Aspartate Decarboxylase-IN-1 is a potent aspartate decarboxylase (PanD) inhibitor with an IC50 value of 56.3 μM. Mab Aspartate Decarboxylase-IN-1 shows antibacterial activity .
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Cat. No.: HY-W011239
CAS No.: 54029-20-8
Synonyms: Oxfendazole sulfone; FBZ-SO2
Domaines de recherche:  

Infection

Fenbendazole sulfone (Oxfendazole sulfone) is a metabolite of Fenbendazole (HY-B0413) and benzimidazole Anthelmintic. Fenbendazole sulfone occurs in cow's milk. Fenbendazole sulfone serves as a marker residue component in cow's milk .
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