33 Results for "

polyols

" in MedChemExpress (MCE) Product Catalog:
Products (33)

33 Results for "polyols" in MCE Product Catalog:

Cat. No.: HY-N12657
Target:  

Others

Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP + (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .
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Cat. No.: HY-N7393R
CAS No.: 64519-82-0
Synonyms: Palatinitol (Standard)
Isomalt (Standard) is the analytical standard of Isomalt. This product is intended for research and analytical applications. Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .
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Cat. No.: HY-N1680
CAS No.: 73815-21-1
3,7-Dimethyloct-1-ene-3,6,7-triol is a class of monoterpenoid polyols. 3, 7-dimethyloct-1-ene-3,6,7-triol has anti-HIV activity. 3, 7-dimethyloct-1-ene-3,6,7-triol can be used to study the isolation method of this drug from natural fruit ofCnidium monnieri .
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Cat. No.: HY-W768347
Synonyms: Xylite-13C5
Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
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Cat. No.: HY-W012846R
CAS No.: 2418-52-2
D-Threitol (Standard) is the analytical standard of D-Threitol (HY-W012846). This product is intended for research and analytical applications. D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC50 of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle .
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Cat. No.: HY-N18991
CAS No.: 15806-48-1
D-Mannitol 1-phosphate is a non-nucleotide phosphate ester. D-Mannitol 1-phosphate is isolable from Lactobacillus arabinosus. D-Mannitol 1-phosphate is associated with active polyol metabolism in Lactobacillus arabinosus .
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Cat. No.: HY-187119
CAS No.: 158575-73-6
Target:  

Aldose Reductase

Research Areas:  

Metabolic Disease

CC13401 is an aldose reductase (ALR2) inhibitor with an IC50 of 41.41 μM in rats. CC13401 inhibits the NADPH-dependent reduction reaction catalyzed by ALR2. CC13401 can be used in studies on the mechanisms related to the polyol pathway and diabetic complications .
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Cat. No.: HY-N7869
CAS No.: 337969-86-5
Celangulin VII is a β-dihydroagarofuran sesquiterpene polyol ester present in the root bark of Celastrus angulatus. Celangulin VII exhibits insecticidal and narcotic activities against the 4th-instar larvae of Mythimna separata. Celangulin VII can be used in insecticide-related research .
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Cat. No.: HY-182496
CAS No.: 181637-98-9
Kanchanamycin A is a 36-membered polyol macrolide antibiotic found in Streptomyces olivaceus Tü 4018, with high activity against Pseudomonas fluorescens, weak activity against Gram-positive bacteria and filamentous fungi, and no activity against yeasts. Kanchanamycin A inhibits growth of Pseudomonas fluorescens, Botrytis cinerea, Mucor miehei, Penicillium notatum, and Staphylococcus aureus. Kanchanamycin A is commonly used in the study of bacterial infections .
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Cat. No.: HY-W133921
CAS No.: 25265-71-8
Research Areas:  

Others

Dipropylene glycol is a mixture of three structural isomers (2-(2-hydroxypropoxy)-1-propanol, 1,1'-oxybis (2-propanol), and 2,2'-oxybis (1-propanol)). Dipropylene glycol induces liver and kidney damage as well as reproductive toxicity in rodents. Dipropylene glycol can be used in chemical industry-related research, such as for plasticizers, polyester resins, cosmetics, fragrances, polyurethane polyols, and alkyd resins .
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Cat. No.: HY-119058
CAS No.: 463976-07-0
Synonyms: CP-744809
Target:  

Aldose Reductase

Research Areas:  

Metabolic Disease

ARI-809 (CP-744809) is a highly selective, orally active aldose reductase inhibitor with an IC50 of 1 nM. ARI-809 blocks excessive glucose flux through the polyol pathway. ARI-809 normalizes elevated sorbitol and fructose levels in sciatic nerve tissues of diabetic rat models, inhibits sorbitol accumulation in lens tissues, and brings elevated urinary albumin excretion close to normal. ARI-809 can be used in diabetes research .
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Cat. No.: HY-184330
Research Areas:  

Metabolic Disease

ALR2/α-Glucosidase-IN-2 is an inhibitor of α-glucosidase and aldose reductase ALR2. ALR2/α-Glucosidase-IN-2 has a Ki value of 11.68 nM against yeast α-glucosidase and a Ki value of 72.64 nM against ovine ALR2. ALR2/α-Glucosidase-IN-2 inhibits intestinal carbohydrate digestion regulatory enzymes and key enzymes in the polyol pathway. ALR2/α-Glucosidase-IN-2 can be used in diabetes-related research .
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Cat. No.: HY-184036
CAS No.: 56759-56-9
3,4,6-Tribromo-5-methylbenzene-1,2-diol (Compound 4) acts as an aldose reductase inhibitor with an IC50 of 1.15 μg/mL. 3,4,6-Tribromo-5-methylbenzene-1,2-diol blocks the conversion of excessive D-glucose (HY-B0389) to D-sorbitol (HY-B0400) via the polyol pathway. 3,4,6-Tribromo-5-methylbenzene-1,2-diol can be used in studies related to diabetic complications .
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