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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
464 Results for "
USP
" in MedChemExpress (MCE) Product Catalog:
Products (464)
464 Results for "USP" in MCE Product Catalog:
Cat. No.: HY-145337
Purity: 99.93%
Synonyms: FT385
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FT3967385 (FT385) is a selective covalent inhibitor that targets the outer mitochondrial membrane deubiquitinase (Deubiquitinase) USP30 (IC50 = 1.5 nM, Ki = 0.014 μM). By inhibiting the enzymatic activity of USP30, FT3967385 relieves its negative regulation of the PINK1-Parkin mediated mitochondrial ubiquitination cascade, thereby enhancing mitophagy. FT3967385 can be used for mechanistic studies of neurodegenerative diseases associated with mitochondrial dysfunction, such as Parkinson's disease .
Cat. No.: HY-168266
CAS No.: 3058588-43-2
Synonyms: XH161-172
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MS1172 (XH161-172; Example 54) is an orally active and potent inhibitor of USP2. MS1172 plays an important role in cancer and virus infection .
Cat. No.: HY-W131289R
CAS No.: 5538-41-0
Synonyms: Chloroxylenol USP RC A (Standard)
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2-Chloro-3,5-dimethylphenol (Standard) is the analytical standard of 2-Chloro-3,5-dimethylphenol. This product is intended for research and analytical applications.
Cat. No.: HY-100900R
CAS No.: 1991986-30-1
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ML364 (Standard) is the analytical standard of ML364 (HY-100900). This product is intended for research and analytical applications. ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP .
Cat. No.: HY-183282
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LC-U7-44 is a potent USP7 inhibitor with an IC50 of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer .
Cat. No.: HY-W653745
CAS No.: 1330266-29-9
Synonyms: Thioguanine-13C2,15N; 2-Amino-6-purinethiol-13C2,15N
Cat. No.: HY-107986R
CAS No.: 2009273-71-4
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GNE-6776 (Standard) is the analytical standard of GNE-6776 (HY-107986). This product is intended for research and analytical applications. GNE-6776 is a selective and orally bioavailable USP7 inhibitor .
Cat. No.: HY-15432
CAS No.: 330450-45-8
Synonyms: (E/Z)-b-AP15
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(E/Z)-NSC-687852 is a isomer of NSC-687852 (HY-13989). NSC687852 (b-AP15) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 .
Cat. No.: HY-138794A
CAS No.: 2417089-73-5
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(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
Cat. No.: HY-112438A
CAS No.: 2758431-95-5
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rac-MF-094 is the racemic mixture of MF-094 (HY-112438). MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy .
Cat. No.: HY-138794G
CAS No.: 2417089-74-6
Cat. No.: HY-114383
CAS No.: 1040754-67-3
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ST-539 is the inhibitor for deubiquitinase USP30 with IC50 of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases .
Cat. No.: HY-180906
CAS No.: 2243090-28-8
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(S,R,S)-AHPC-C2-PEG3-NH2 is an E3 ligase ligand-linker conjugate, can be used for synthesis of PROTAC USP39 Degrader-1 (HY-180907) .
Cat. No.: HY-141659A
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(R)-CMPD-39 is the R enantiomer of CMPD-39 ( HY-141659 ). CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50 =~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .
Cat. No.: HY-P85431
Synonyms: USP7; HAUSP; Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
Cat. No.: HY-13453R
CAS No.: 19542-67-7
Synonyms: BAY 11-7821 (Standard)
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BAY 11-7082 (Standard) is the analytical standard of BAY 11-7082 (HY-13453). This product is intended for research and analytical applications. BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
Cat. No.: HY-D1236
CAS No.: 16090-02-1
Cat. No.: HY-W008708R
CAS No.: 55198-89-5
Synonyms: ClonazepaM USP Related CoMpound A (Standard)
Target:
3-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one (Standard) is the analytical standard of 3-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one. This product is intended for research and analytical applications.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
