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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
BAD
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "BAD" in MCE Product Catalog:
Cat. No.: HY-180948
Target:
Research Areas:
PZ-11 is a derivative of thiazolidinedione with anti-tumor activity. PZ-11 can induce cancer cells apoptosis by downregulating anti-apoptotic gene AIFM1, BAG3 and BIRC3 and regulating pro-apoptotic gene BAD, HRK, CASP10 and CASP10. PZ-11 can be used for research of breast cancer .
Cat. No.: HY-P77978
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LAMP5; DJ1119D9.3; Prev. C20orf103; Lysosomal-Associated Membrane Protein Family, Member 5; BAD-LAMP; Brain And Dendritic Cell Associated LAMP; Lysosomal Associated Membrane Protein Family Member 5; Lysosome-Associated Membrane Protein 5; UNC-46; Chromoso
Species:
Human
Source:
HEK293
Cat. No.: HY-P700775
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LAMP5; DJ1119D9.3; Prev. C20orf103; Lysosomal-Associated Membrane Protein Family, Member 5; BAD-LAMP; Brain And Dendritic Cell Associated LAMP; Lysosomal Associated Membrane Protein Family Member 5; Lysosome-Associated Membrane Protein 5; UNC-46; Chromoso
Species:
Human
Source:
HEK293
Cat. No.: HY-P702954
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BAD; Bcl-2-Like Protein 8; BCL2 Associated Agonist Of Cell Death; Bcl2-L-8; BCL2L8; BCL2-Antagonist Of Cell Death Protein; BBC2; BCL-X/BCL-2 Binding Protein; Bcl-XL/Bcl-2-Associated Death Promoter; BCL2-Binding Component 6; Bcl2-Associated Agonist Of Cell
Species:
Human
Source:
E. coli
Cat. No.: HY-180150
Research Areas:
PROTAC BRD4 Degrader-42 (Compound P6) is a PROTAC-based BRD4 degrader with a DC50 of 1.11 μM. PROTAC BRD4 Degrader-42 promotes the ubiquitination and degradation of BRD4. PROTAC BRD4 Degrader-42 downregulates c-Myc expression and induces Apoptosis by upregulating BAD and BAX protein expression. PROTAC BRD4 Degrader-42 also exhibits anticancer activity against myeloid monocytic leukemia .
Cat. No.: HY-181925
FD2024 is a pan-PIM kinase inhibitor with IC50 values of 0.17 nM, 1.86 nM, and 0.38 nM against PIM-1, PIM-2, and PIM-3, respectively. FD2024 induces cell apoptosis. FD2024 inhibits the phosphorylation of mTOR, p70S6K, S6, 4EBP1, and BAD proteins. FD2024 exhibits anti-acute myeloid leukemia activity. FD2024 can be used in studies related to acute myeloid leukemia .
Cat. No.: HY-111552R
CAS No.: 1417630-95-5
Target:
Research Areas:
PIM1-IN-1 (Standard) is the analytical standard of PIM1-IN-1 (HY-111552). This product is intended for research and analytical applications. PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity .
Cat. No.: HY-180190
Research Areas:
Tubulin polymerization-IN-85 (Compound C21) is a tubulin polymerization inhibitor (IC50 = 1.59 μM) targeting the colchicine binding site. Tubulin polymerization-IN-85 can cause cancer cells G2/M phase arrest and induce apoptosis. Tubulin polymerization-IN-85 downregulates the expression of Bcl-2, Bcl-xl, Mcl-1, Cyclin B1, cdc25, cdc2 protein and upregulates P53, P21, Bad and Bax levels. Tubulin polymerization-IN-85 can be used for the research of cancer, such as cervical cancer .
Cat. No.: HY-P77733
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LAMP5; DJ1119D9.3; Prev. C20orf103; Lysosomal-Associated Membrane Protein Family, Member 5; BAD-LAMP; Brain And Dendritic Cell Associated LAMP; Lysosomal Associated Membrane Protein Family Member 5; Lysosome-Associated Membrane Protein 5; UNC-46; Chromoso
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P700774
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LAMP5; DJ1119D9.3; Prev. C20orf103; Lysosomal-Associated Membrane Protein Family, Member 5; BAD-LAMP; Brain And Dendritic Cell Associated LAMP; Lysosomal Associated Membrane Protein Family Member 5; Lysosome-Associated Membrane Protein 5; UNC-46; Chromoso
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-113720
CAS No.: 1041469-97-9
Target:
CDK Apoptosis Caspase Reactive Oxygen Species (ROS) JNK MDM-2/p53 Bcl-2 Family IGF-1R PI3K PKC Ras Akt
Research Areas:
RKS262 is an orally active cyclin/CDK inhibitor. RKS262 is also an apoptosis inducer and cell cycle regulator, exhibiting cytotoxic activity against cancer cells. RKS262 induces caspase-3 cleavage, ROS generation, SAPK/JNK activation, and upregulates the expression of p53, Bid, Bad, Bok, and p27. RKS262 inhibits the expression of Bcl-2, Mcl-1, Bcl-xL, p21, cyclin D1, cyclin B1, cdc-2, cyclin D4, and DNA-pk KU-80 subunit. RKS262 suppresses the phosphorylation of the IGF-1R/PI3K/PKC pathway, ras oncogene activity, and Cdk-6, while increasing total Akt expression. RKS262 induces G2/M or S phase cell cycle arrest, disrupts mitochondrial transmembrane potential, and reduces tumor burden in xenograft models. RKS262 is used in research on neuroblastoma and ovarian cancer .
Cat. No.: HY-122670
CAS No.: 1627962-21-3
VS-II-173 is a pan-Pim kinase inhibitor with IC50 values of 0.07 μM and 0.02 μM for Pim1 and Pim3, respectively, and a residual activity of 46% for Pim2 at 1 μM. VS-II-173 also inhibits kinases such as HIPK2, PRK2, RSK1, DYRK1a and AMPKα1, selectively inhibiting acute myeloid leukemia (AML) cells with significantly lower toxicity to non-malignant cells (EC50 > 30 μM). VS-II-173 weakens the phosphorylation of substrates such as Stat5 (Y694), MDM2 (S166), Bad (S112), and 4E-BP1 (T37/46) by inhibiting Pim kinase-mediated signaling pathways, blocking pro-survival signals in AML cells and inducing apoptosis. VS-II-173 synergistically enhances anti-AML activity when combined with Daunorubicin (HY-13062A). VS-II-173 can be used in AML research, especially for AML with FLT3-ITD mutations and NPM1 mutations .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
